Kmo - kynurenine 3-monooxygenase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59113

Summary

Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Kmo Products (1)

mRNA Protein Name
NM_021593.2 NP_067604.1 kynurenine 3-monooxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kynurenine 3-monooxygenase activity IDA
IDA: Inferred from direct assay
1332540 RGD
Biological Process GO Annotation Evidence References Source
involved in L-kynurenine metabolic process IDA
IDA: Inferred from direct assay
23690293 RGD
involved in NAD metabolic process IDA
IDA: Inferred from direct assay
1332540 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
25675848 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
26524415 RGD
involved in kynurenic acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
15829251 RGD
involved in kynurenine metabolic process IDA
IDA: Inferred from direct assay
26752518 RGD
involved in positive regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
15829251 RGD
involved in positive regulation of glutamate secretion, neurotransmission IMP
IMP: Inferred from mutant phenotype
15829251 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18584961 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
29217494 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
1332540 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kynurenine 3-monooxygenase

  • kynurenine 3-hydroxylase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12347 Ro 61-8048 Inhibitor 99.93% Unkown
HY-111365 TES-1025 Inhibitor 98.39% Unkown
HY-112179 GSK180 Inhibitor 98.34% Unkown
HY-W748591 Cannflavin A Inhibitor 99.20% Unkown
HY-119171 GSK 366 Inhibitor 98.17% Unkown
HY-182456 CHDI-340246 Inhibitor / Unkown
HY-182692 KMO-IN-1 Inhibitor / Unkown
HY-15500 JM6 Inhibitor / Unkown
HY-181988 DTB-acid / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kmo NCBI NCBI:8564