KMO - kynurenine 3-monooxygenase Gene

Also Known as dJ317G22.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8564

About KMO

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,532,378-241,595,642 (from NCBI)

This gene has 10 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in liver (RPKM 11.5), kidney (RPKM 9.8) and 20 other tissues.

Summary

This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]

KMO Products (2)

mRNA	Protein	Name
NM_001410944.1	NP_001397873.1	kynurenine 3-monooxygenase isoform 2
NM_003679.5	NP_003670.2	kynurenine 3-monooxygenase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables FAD binding	IDA IDA: Inferred from direct assay	29429898	GOA
enables NAD(P)H oxidase H2O2-forming activity	IDA IDA: Inferred from direct assay	10672018	GOA
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	10672018	GOA
enables kynurenine 3-monooxygenase activity	IDA IDA: Inferred from direct assay	9237672	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NAD metabolic process	IDA IDA: Inferred from direct assay	23575632	GOA
involved in kynurenine metabolic process	IDA IDA: Inferred from direct assay	10672018	GOA
involved in response to salt stress	IDA IDA: Inferred from direct assay	10672018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KMO Protein Structure

FAD_binding_3

0
100
200
300
400
486 a.a.

Protein Preferred Names	Protein Names
kynurenine 3-monooxygenase	kynurenine 3-hydroxylase

Related Diseases

Diseases	Alias
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Streptococcal Meningitis
Huntington Disease	Huntington'S Disease Huntington Chorea Huntington'S Chorea HD Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Intracranial Vasospasm	Vasospasm, Intracranial
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12347	Ro 61-8048	Inhibitor	99.93%	Unkown
HY-111365	TES-1025	Inhibitor	98.39%	Unkown
HY-112179	GSK180	Inhibitor	98.34%	Unkown
HY-W748591	Cannflavin A	Inhibitor	99.20%	Unkown
HY-119171	GSK 366	Inhibitor	98.17%	Unkown
HY-182456	CHDI-340246	Inhibitor	/	Unkown
HY-182692	KMO-IN-1	Inhibitor	/	Unkown
HY-15500	JM6	Inhibitor	/	Unkown
HY-181988	DTB-acid		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KMO	MGD	MGI:2138151
Macaca mulatta	KMO	VGNC	VGNC:74197
Canis familiaris	KMO	VGNC	VGNC:42488
Rattus norvegicus	KMO	RGD	RGD:620610
Bos taurus	KMO	VGNC	VGNC:30689
Felis catus	KMO	VGNC	VGNC:67970
Others	KMO	NCBI