Phlpp1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

Also Known as Scop; Phlpp; Plekhe1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59265

Summary

Enables protein serine/threonine Phosphatase activity. Involved in several processes, including hippocampus development; protein dephosphorylation; and regulation of intracellular signal transduction. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Phlpp1 Products (1)

mRNA Protein Name
NM_021657.2 NP_067689.2 PH domain leucine-rich repeat protein phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
20089132 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
10570941 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
20819118 RGD
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20819118 RGD
involved in negative regulation of protein kinase C signaling IMP
IMP: Inferred from mutant phenotype
20819118 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20819118 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
20089132 RGD
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
20819118 RGD
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
20819118 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20819118 RGD
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
20819118 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
20819118 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
20819118 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
20819118 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PH domain leucine-rich repeat protein phosphatase 1

  • Circadian Oscillatory Protein (SCOP)

  • PH domain leucine-rich repeat-containing protein phosphatase 1

  • PH domain-containing family E member 1

  • SCN circadian oscillatory protein

  • pleckstrin homology domain containing, family E (with leucine rich repeats) me

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19820A NSC45586 sodium 98.0% Unkown
HY-19820 NSC45586 / Unkown
HY-RS10447 PHLPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18428 Phlpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24909 Phlpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Phlpp1 NCBI NCBI:23239