RXFP1 - relaxin family peptide receptor 1 Gene

Homo sapiens

Also known as LGR7; RXFPR1

Gene ID: 59350 | Gene type: protein coding

About RXFP1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,521,714-158,653,372 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 22 paralogues. Biased expression in brain (RPKM 6.2), endometrium (RPKM 3.9) and 7 other tissues.

Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

RXFP1 Products(8)

mRNA	Protein	Name
NM_001253727.2	NP_001240656.1	relaxin receptor 1 isoform 2
NM_001253728.2	NP_001240657.1	relaxin receptor 1 isoform 3
NM_001253729.2	NP_001240658.1	relaxin receptor 1 isoform 4
NM_001253730.2	NP_001240659.1	relaxin receptor 1 isoform 5
NM_001253732.2	NP_001240661.1	relaxin receptor 1 isoform 6
NM_001253733.2	NP_001240662.1	relaxin receptor 1 isoform 7
NM_001363776.1	NP_001350705.1	relaxin receptor 1 isoform 8
NM_021634.4	NP_067647.2	relaxin receptor 1 isoform 1

RXFP1 Protein Structure

Ldl_recept_a

LRR_8

7tm_1

0
200
400
600
757 a.a.

Protein Preferred Names

Protein Names

relaxin receptor 1

leucine-rich repeat-containing G protein-coupled receptor 7

Recombinant RXFP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79304	Relaxin R1 Protein, Human (CHO, hFc)	Q9HBX9 (Q23-S398)	≥95%

Related Diseases

Diseases

Alias

Radiation Cystitis

Irradiation Cystitis

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Placenta Accreta

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148087	AZD5462		99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112606	ML-290		98.77%	Unkown
HY-P4890A	Relaxin H3 (human) (TFA)		/	Unkown
HY-156536	RXFP1 receptor agonist-1		/	Unkown
HY-156537	RXFP1 receptor agonist-2		/	Unkown
HY-156538	RXFP1 receptor agonist-3		/	Unkown
HY-156539	RXFP1 receptor agonist-4		/	Unkown
HY-156540	RXFP1 receptor agonist-5		/	Unkown
HY-156541	RXFP1 receptor agonist-6		/	Unkown
HY-156542	RXFP1 receptor agonist-7		/	Unkown
HY-156543	RXFP1 receptor agonist-8		/	Unkown
HY-162401	AZ7976	Antagonist	/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-RS12357	RXFP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RXFP1	VGNC	VGNC:64831
Bos taurus	RXFP1	VGNC	VGNC:52820
Macaca mulatta	RXFP1	VGNC	VGNC:77056
Mus musculus	RXFP1	MGD	MGI:2682211
Rattus norvegicus	RXFP1	RGD	RGD:1302973
Canis familiaris	RXFP1	VGNC	VGNC:54222

Name
Email *

	Sorry, but the email address you supplied was invalid.