RXFP1 - relaxin family peptide receptor 1 Gene

Also Known as LGR7; RXFPR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59350

About RXFP1

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:158,521,714-158,653,372 (from NCBI)

This gene has 11 transcripts (splice variants), 200 orthologues and 22 paralogues. Biased expression in brain (RPKM 6.2), endometrium (RPKM 3.9) and 7 other tissues.

Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

RXFP1 Products (8)

mRNA Protein Name
NM_001253727.2 NP_001240656.1 relaxin receptor 1 isoform 2
NM_001253728.2 NP_001240657.1 relaxin receptor 1 isoform 3
NM_001253729.2 NP_001240658.1 relaxin receptor 1 isoform 4
NM_001253730.2 NP_001240659.1 relaxin receptor 1 isoform 5
NM_001253732.2 NP_001240661.1 relaxin receptor 1 isoform 6
NM_001253733.2 NP_001240662.1 relaxin receptor 1 isoform 7
NM_001363776.1 NP_001350705.1 relaxin receptor 1 isoform 8
NM_021634.4 NP_067647.2 relaxin receptor 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
11809971 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20664520 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXFP1 Protein Structure

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (26 - 62)

LRR_8

LRR_8: Leucine rich repeat (127 - 186)

LRR_8

LRR_8: Leucine rich repeat (247 - 307)

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (422 - 681)

  • 0
  • 200
  • 400
  • 600
  • 757 a.a.
Protein Preferred Names Protein Names

relaxin receptor 1

  • leucine-rich repeat-containing G protein-coupled receptor 7

Related Diseases

Diseases Alias
Radiation Cystitis

  • Irradiation Cystitis
Endometriosis

  • Endometriosis, Site Unspecified

  • Endometrial Ectopia
Placenta Accreta
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-148087 AZD5462 99.89% Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112606 ML-290 99.75% Unkown
HY-P10728 B7-33 99.31% Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-156536 RXFP1 receptor agonist-1 / Unkown
HY-156537 RXFP1 receptor agonist-2 / Unkown
HY-156538 RXFP1 receptor agonist-3 / Unkown
HY-156539 RXFP1 receptor agonist-4 / Unkown
HY-156540 RXFP1 receptor agonist-5 / Unkown
HY-156541 RXFP1 receptor agonist-6 / Unkown
HY-156542 RXFP1 receptor agonist-7 / Unkown
HY-156543 RXFP1 receptor agonist-8 / Unkown
HY-162401 AZ7976 Agonist / Unkown
HY-176215 RXFP1 receptor agonist-10 Agonist / Unkown
HY-P11619 R2R01 Agonist / Unkown
HY-P11625 R9-13 Activator / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-RS12357 RXFP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174334 RXFP1 receptor agonist-9 Inhibitor / Unkown
HY-RS19738 Rxfp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26234 Rxfp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992258 Anti-LGR7 Antibody / Unkown
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RXFP1 VGNC VGNC:64831
Bos taurus RXFP1 VGNC VGNC:52820
Macaca mulatta RXFP1 VGNC VGNC:77056
Mus musculus RXFP1 MGD MGI:2682211
Rattus norvegicus RXFP1 RGD RGD:1302973
Canis familiaris RXFP1 VGNC VGNC:54222