RBMS2 - RNA binding motif single stranded interacting protein 2 Gene

Also Known as SCR3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5939

About RBMS2

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,520,405-56,596,193 (from NCBI)

This gene has 9 transcripts (splice variants), 278 orthologues and 24 paralogues. Broad expression in lung (RPKM 17.5), placenta (RPKM 15.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and Apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

RBMS2 Products (4)

mRNA Protein Name
NM_001414459.1 NP_001401388.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 2
NM_001414460.1 NP_001401389.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 3
NM_001414461.1 NP_001401390.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 1
NM_002898.4 NP_002889.1 RNA-binding motif, single-stranded-interacting protein 2 isoform 1

RBMS2 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (58 - 118)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (137 - 201)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
Protein Preferred Names Protein Names

RNA-binding motif, single-stranded-interacting protein 2

  • suppressor of CDC2 with RNA-binding motif 3

Related Diseases

Diseases Alias
Hemolytic Uremic Syndrome, Atypical 1

  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11761 RBMS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21726 Rbms2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28243 Rbms2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RBMS2 VGNC VGNC:45428
Felis catus RBMS2 VGNC VGNC:69269
Mus musculus RBMS2 MGD MGI:1861776
Macaca mulatta RBMS2 VGNC VGNC:76687
Bos taurus RBMS2 VGNC VGNC:33810
Rattus norvegicus RBMS2 RGD RGD:1304813
Others RBMS2 NCBI