2. Gene
  3. RGS13 - regulator of G protein signaling 13 Gene

RGS13 - regulator of G protein signaling 13 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 6003 | Gene type: protein coding

About RGS13

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,636,147-192,660,311 (from NCBI)

This gene has 4 transcripts (splice variants), 262 orthologues and 23 paralogues. Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]

RGS13 Products(2)

mRNA Protein Name
NM_002927.5 NP_002918.1 regulator of G-protein signaling 13
NM_144766.3 NP_658912.1 regulator of G-protein signaling 13

RGS13 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (34 - 149)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 13

regulator of G-protein signalling 13

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11906 RGS13 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RGS13 VGNC VGNC:45523
Rattus norvegicus RGS13 RGD RGD:1562103
Macaca mulatta RGS13 VGNC VGNC:76917
Bos taurus RGS13 VGNC VGNC:33913
Mus musculus RGS13 MGD MGI:2180585
Felis catus RGS13 VGNC VGNC:107930