Il1rn - interleukin 1 receptor antagonist Gene

Also Known as IL-1ra

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60582

Summary

Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Il1rn Products (1)

mRNA Protein Name
NM_022194.2 NP_071530.1 interleukin-1 receptor antagonist protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 receptor binding IDA
IDA: Inferred from direct assay
1834644 RGD
Biological Process GO Annotation Evidence References Source
involved in carboxylic acid metabolic process IEP
IEP: Inferred from expression pattern
9685640 RGD
involved in cellular response to norepinephrine stimulus IEP
IEP: Inferred from expression pattern
19818755 RGD
involved in chronic inflammatory response to antigenic stimulus IEP
IEP: Inferred from expression pattern
15050649 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
14603373 RGD
involved in fever generation IMP
IMP: Inferred from mutant phenotype
16455768 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
15050649 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16038625 RGD
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
21244430 RGD
involved in negative regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
12667655 RGD
involved in negative regulation of membrane potential IDA
IDA: Inferred from direct assay
20554014 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
12667655 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22117073 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
8906613 RGD
involved in response to interleukin-4 IEP
IEP: Inferred from expression pattern
8409406 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17138728 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15751073 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
22117073 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15837124 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17138728 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor antagonist protein

  • IL-1RN

  • IL1 inhibitor

  • IRAP

Recombinant Il1rn Proteins

Cat. No. Product Name Accession Purity
HY-P73187 IL-1RA/IL-1RN Protein, Rat (HEK293, Fc) P25086 (H27-Q178) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P73894 IL-1RA/IL-1RN Protein, Rat (His, solution) P25086 (H27-Q178) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75853 IL-1RA/IL-1RN Protein, Cynomolgus (His) NP_001270468.1 (R26-E177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73894A IL-1RA/IL-1RN Protein, Rat (His) P25086 (H27-Q178) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06727 IL1RN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17664 Il1rn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24125 Il1rn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1rn NCBI NCBI:3557