S100A8 - S100 calcium binding protein A8 Gene

Also Known as P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; S100-A8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6279

About S100A8

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,390,032-153,422,583 (from NCBI)

This gene has 3 transcripts (splice variants), 346 orthologues and 21 paralogues. Biased expression in bone marrow (RPKM 3778.8), esophagus (RPKM 2115.4) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of Casein Kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

S100A8 Products (5)

mRNA	Protein	Name
NM_001319196.1	NP_001306125.1	protein S100-A8 isoform a
NM_001319197.1	NP_001306126.1	protein S100-A8 isoform b
NM_001319198.2	NP_001306127.1	protein S100-A8 isoform c
NM_001319201.2	NP_001306130.1	protein S100-A8 isoform d
NM_002964.5	NP_002955.2	protein S100-A8 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9867828	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	19935772	GOA
involved in autophagy	IDA IDA: Inferred from direct assay	19935772	GOA
involved in leukocyte migration involved in inflammatory response	IDA IDA: Inferred from direct assay	12626582	GOA
involved in neutrophil aggregation	IDA IDA: Inferred from direct assay	12626582	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	12626582	GOA
involved in peptidyl-cysteine S-nitrosylation	IMP IMP: Inferred from mutant phenotype	25417112	GOA
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	12626582	GOA
involved in positive regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19935772	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calprotectin complex	IPI IPI: Inferred from physical interaction	25597447	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	21805676	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A8 Protein Structure

S_100

0
93 a.a.

Protein Preferred Names	Protein Names
protein S100-A8	calgranulin A

S100A8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	S100A8	P05109	S100A9	Homo sapiens	P06702	Anti Bait CoIP	25417112
Intra	S100A8	P05109	S100A9	Homo sapiens	P06702	Anti Tag CoIP	25417112
Intra	S100A8	P05109	S100A9	Homo sapiens	P06702	Y2H	9867828
Intra	S100A8	P05109	TRPM4	Homo sapiens	Q8TD43	FPS	31837246
Intra	S100A8	P05109	GAPDH	Homo sapiens	P04406	Anti Tag CoIP	25417112
Intra	S100A8	P05109	GAPDH	Homo sapiens	P04406	Anti Bait CoIP	25417112

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant S100A8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71076	S100A8-S100A9 Heterodimer Protein, Human (His, solution)	P05109 (M1-E93) (S100A8)&P06702 (T2-P114) (S100A9)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P76586	S100A8 Protein, Human (sf9, His)	P05109 (M1-E93)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P70531A	S100A8 Protein, Human (N-His)	P05109 (M1-E93)	≥ 90%, as determined by reducing SDS-PAGE.

S100A8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81425	S100 A8 Antibody (YA1170)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human
HY-P85718	S100 A8+A9 Antibody (YA5410)	IHC-P	Human
HY-P85719	S100 A8 Antibody (YA5411)	IHC-P, WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Peptic Ulcer Disease	Peptic Ulcer Acute Peptic Ulcer With Hemorrhage Acute Peptic Ulcer With Hemorrhage And Perforation Acute Peptic Ulcer Without Hemorrhage And Without Perforation
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Atrophic Gastritis	Gastritis, Atrophic Gastric Atrophy Gastritis Atrophic
Gastritis	Acute Gastric Mucosal Erosion Erosive Gastritis Erosive Gastropathy Gastritis Erosive Idiopathic Erosive/Hemorrhagic Gastritis Inflammation Of Gastric Mucosa Gastroduodenitis Gastritis Nos Noninfectious Gastroenteritis Nonbacterial Gastroenteritis Of Infant Acute Gastric Infection Acute Simple Gastritis Chronic Antral Gastritis Chronic Fundal Gastritis Chronic Simple Gastritis Acute Gastroduodenitis Acute Antral Gastritis Acute Erosive Gastritis Bile Reflux Gastritis Gastritis Due To Biliary Reflux
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Duodenum Disease	Duodenal Diseases Duodenal Disease Duodenum Disorder
Gastrointestinal System Disease	Gastrointestinal Disease Gastrointestinal Diseases Alimentary System Disease Digestive System Disorder Gastroenteropathy Gastrointestinal Disorder Git Disease Digestive System Diseases Gastrointestinal Disorders Digestive System Disease Digestive System Disorders
Peptic Ulcer Perforation	Perforated Peptic Ulcer Acute Peptic Ulcer With Perforation Peptic Ulcer With Perforation
Duodenitis	Hemorrhagic Duodenitis Acute Enteritis Of The Mouse Intestinal Tract Nonspecific Duodenitis Inflammation Of Duodenum Dodecadactylitis Duodenal Inflammation Peptic Duodenitis
Gastric Lymphoma	Familial Primary Gastric Lymphoma Lymphoma Of The Stomach Primary Gastric Lymphoma
Gastric Ulcer	Stomach Ulcer Acute Gastric Ulcer With Haemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction Acute Gastric Ulcer With Hemorrhage, With Obstruction Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction Acute Gastric Ulcer With Perforation Acute Gastric Ulcer With Perforation And Obstruction Acute Gastric Ulcer With Perforation, With Obstruction Acute Gastric Ulcer Without Hemorrhage And Without Perforation Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction Bleeding Acute Gastric Ulcer Chronic Gastric Ulcer Without Hemorrhage And Without Perforation Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction Gastric Ulcers Cushings Ulcer Cushing'S Ulcer Of Stomach Peptic Ulcer Of Stomach Mucosal Defect Of The Stomach
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Juvenile Rheumatoid Arthritis	Juvenile Idiopathic Arthritis Juvenile Chronic Polyarthritis Monarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Arthritis Still'S Disease Systemic Juvenile Rheumatoid Arthritis Juvenile Chronic Arthritis Acute Juvenile Rheumatoid Arthritis Pauciarticular Onset Juvenile Chronic Arthritis Arthritis, Juvenile Rheumatoid Jia Jra Juvenile Ra Arthritis Juvenile Rheumatoid Stills Disease Juvenile Arthritis Acute Polyarticular Juvenile Rheumatoid Arthritis Pauciarticular Juvenile Rheumatoid Arthritis Rheumatoid Arthritis, Systemic Juvenile
Gastric Adenocarcinoma	Adenocarcinoma Of Stomach Stomach Adenocarcinoma Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Of Unspecified Site Diffuse Type Adenocarcinoma Of Unspecified Site
Cardia Cancer	Ca Cardia - Stomach Malignant Neoplasm Of Cardia Of Stomach
Microinvasive Gastric Cancer	Early Gastric Cancer Surface Gastric Cancer
Psoriasis
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cholesteatoma Of Middle Ear	Cholesteatoma Epidermosis Of Ear Epidermosis Of Middle Ear Middle Ear Cholesteatoma Cholesteatoma Of Middle Ear And Mastoid Cholesteatoma Of Middle Ear And/Or Mastoid Cholesteatoma Of The Middle Ear Congenital Cholesteatoma Primary Acquired Cholesteatoma Secondary Acquired Cholesteatoma Cholesteatoma Middle Ear Cholesteatoma, Middle Ear Cholesterolosis Of Middle Ear Cholesterosis Of Ear Cholesterosis Of Middle Ear Cholesteatoma Nos Epidermoid Cholesteatoma Middle Ear Granuloma
Rosacea	Erythematotelangiectatic Rosacea Papulopustular Rosacea Phymatous Rosacea Acne Roscea Acne, Erythematosa Granulomatous Rosacea Ocular Rosacea Acne Rosacea Hypertrophic Rosacea
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Esophagus Melanoma	Melanoma Of Esophagus Melanoma Of Oesophagus Oesophagus Melanoma Esophageal Melanoma
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Appendicitis	Acute Appendicitis Acute Appendicitis With Generalized Peritonitis Acute Appendicitis Nos Acute Appendicitis With Peritoneal Abscess Appendiceal Inflammation Appendicitis, Unqualified Acute Appendix Inflammation Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation Acute Appendicitis With Free Peritonitis Acute Appendicitis With Free Perforation To The Abdominal Cavity Perforated Appendix With Generalised Peritonitis Appendicitis With Perforation And Free Pus In The Peritoneal Cavity Perforated Appendix With Localised Peritonitis Acute Appendicitis With Contained Perforation To A Localised Abscess Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess Appendicitis With Abscess Appendicitis With Peritoneal Abscess Ruptured Appendix Nos Acute Appendicitis With No Perforation Or Abscess And No Visible Pus Acute Appendicitis With No Specification If Perforated Or Not Acute Appendicitis With Phlegmone
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Fungal Gastritis
Peptic Esophagitis	Reflux Esophagitis Peptic Reflux Disease Reflux Oesophagitis Esophagitis, Peptic Gastro-Esophageal Reflux Disease With Esophagitis
Squamous Blepharitis
Gastroesophageal Reflux	Gastroesophageal Reflux Disease Gerd GER Gastroesophageal Reflux, Pediatric Acid Reflux Gastresophageal Reflux Gastro-Esophageal Reflux Gerd - Gastro-Esophageal Reflux Disease
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Onchocerciasis	Infection By Onchocerca Volvulus River Blindness Onchocerca Volvulus Infection Volvulosis Robles' Disease Onchocerciasis, Ocular Robles Disease Onchocercosis Blinding Filariasis Robles Onchocerca Infestation Craw-Craw
Renal Infectious Disease
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Granulomatous Gastritis
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Autoimmune Gastritis
Marginal Zone B-Cell Lymphoma	Marginal Zone Lymphoma Mzl Mucosa-Associated Lymphoid Tissue Lymphoma
Bile Reflux
Larynx Squamous Papilloma	Laryngeal Squamous Cell Papilloma
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Diffuse Gastric And Lobular Breast Cancer Syndrome	Hereditary Diffuse Gastric Cancer HDGC LBC Familial Diffuse Gastric Cancer Fdgc Hereditary Diffuse Gastric Adenocarcinoma Breast Cancer, Lobular Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate DGLBC Gastric Cancer, Hereditary Diffuse Gastric Cancer, Familial Diffuse Breast Cancer, Lobular Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate E-Cadherin-Associated Hereditary Gastric Cancer Familial Diffuse Cancer Of Stomach Hereditary Diffuse Cancer Of Stomach Gastric Cancer Familial Diffuse Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate Cancer, Gastric, Hereditary Diffuse
Spondylarthropathy	Spondylarthropathies
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100442	Paquinimod	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141537	ABR-238901	Inhibitor	98.92%	Unkown
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	Unkown
HY-RS16593	S100a8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12385	S100A8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100442S	Paquinimod-d5	Inhibitor	/	Unkown
HY-RS23027	S100a8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	S100A8	VGNC	VGNC:64842
Rattus norvegicus	S100A8	RGD	RGD:620265
Canis familiaris	S100A8	VGNC	VGNC:45833
Bos taurus	S100A8	VGNC	VGNC:34246
Macaca mulatta	S100A8	VGNC	VGNC:100128
Mus musculus	S100A8	MGD	MGI:88244
Others	S100A8	NCBI