Per2 - period circadian regulator 2 Gene

Also Known as rPER2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63840

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

Per2 Products (1)

mRNA Protein Name
NM_031678.2 NP_113866.1 period circadian protein homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9765215 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
9765215 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12397359 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12397359 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
20589906 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 2

  • circadian clock protein PERIOD 2

  • period circadian clock 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119506 KL044 99.50% Unkown
HY-136093B Lixumistat 99.33% Unkown
HY-RS20323 Per2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10332 PER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26831 Per2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Per2 NCBI NCBI:8864