Sp5 - trans-acting transcription factor 5 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64406

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within bone morphogenesis; cellular response to organic cyclic compound; and post-anal tail morphogenesis. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo ectoderm; and embryo mesenchyme. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp5 Products (1)

mRNA Protein Name
NM_022435.2 NP_071880.1 transcription factor Sp5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17090534 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11071760 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11071760 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone morphogenesis IGI
IGI: Inferred from genetic interaction
11071760 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
25535395 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17090534 MGI
acts upstream of or within post-anal tail morphogenesis IGI
IGI: Inferred from genetic interaction
11071760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor Sp5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-20897A 5-Bromo-L-tryptophan 99.78% Unkown
HY-RS13608 SP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-137638 Sp-5,6-DCl-cBIMPS Activator / Unkown
HY-137638A Sp-5,6-DCl-cBIMPS sodium Activator / Unkown
HY-RS12783 SFTPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W456555 (SP-5-12)-Chloro[[1,1′,1′′,1′′′-tetramethyl 4,4′,4′′,4′′′-(21H,23H-porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzoato]](2-)]iron / Unkown
HY-W855975 (SP-5-12)-Chloro[[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl-κN21,κN22,κN23,κN24)tetrakis[benzoato]](6-)]Ferrate(3-) / Unkown
HY-W855976 (SP-5-12)-Chloro[5,10,15,20-tetrakis(4-bromophenyl)-21H,23H-porphinato(2-)-N21,N22,N23,N24]iron / Unkown
HY-W855977 (SP-5-12)-Chloro[5,10,15,20-tetrakis(4-bromophenyl)-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]manganese / Unkown
HY-RS17444 Sp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21754 Sftpc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23900 Sp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991311 GSK3178022 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sp5 NCBI NCBI:389058