ILRUN - inflammation and lipid regulator with UBA-like and NBR1-like domains Gene

Also Known as FP852; C6orf106; dJ391O22.4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64771

About ILRUN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,587,288-34,696,767 (from NCBI)

This gene has 3 transcripts (splice variants) and 262 orthologues. Ubiquitous expression in fat (RPKM 19.9), testis (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a protein with N-terminal ubiquitin-associated (UBA)-like and central neighbor of BRCA1 gene 1 (NBR1)-like domains. The protein acts an inhibitor of Antiviral and proinflammatory cytokine transcription and as a regulator of the renin-angiotensin-aldosterone system (RAAS). [provided by RefSeq, Jul 2021]

ILRUN Products (2)

mRNA Protein Name
NM_022758.6 NP_073595.2 protein ILRUN isoform b
NM_024294.4 NP_077270.1 protein ILRUN isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
29802199 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA binding IDA
IDA: Inferred from direct assay
29802199 GOA
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
29802199 GOA
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
29802199 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
29802199 GOA
involved in negative regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
29802199 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
29802199 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29802199 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ILRUN Protein Structure

UBA_4

UBA_4: UBA-like domain (26 - 66)

  • 0
  • 100
  • 200
  • 298 a.a.
Protein Preferred Names Protein Names

protein ILRUN

  • inflammation and lipid regulator with UBA-like and NBR1-like domains protein

Related Diseases

Diseases Alias
Meninges Sarcoma

  • Meningeal Sarcoma

  • Sarcoma Of Meninges

  • Meningothelial Sarcoma

  • Leptomeningeal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06789 ILRUN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ILRUN RGD RGD:1559829
Mus musculus ILRUN MGD MGI:106281
Macaca mulatta ILRUN VGNC VGNC:83428
Bos taurus ILRUN VGNC VGNC:52675
Canis familiaris ILRUN VGNC VGNC:49210
Felis catus ILRUN VGNC VGNC:102443