SLIT3 - slit guidance ligand 3 Gene

Also Known as MEGF5; SLIL2; SLIT1; slit2; Slit-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6586

About SLIT3

Cytogenetic location: 5q34-q35.1 Genomic coordinates (GRCh38): 5:168,661,740-169,301,139 (from NCBI)

This gene has 8 transcripts (splice variants), 199 orthologues and 25 paralogues. Broad expression in fat (RPKM 23.0), gall bladder (RPKM 21.4) and 22 other tissues.

Summary

The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

SLIT3 Products (2)

mRNA Protein Name
NM_001271946.2 NP_001258875.2 slit homolog 3 protein isoform 1 precursor
NM_003062.4 NP_003053.2 slit homolog 3 protein isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Roundabout binding IPI
IPI: Inferred from physical interaction
15207848 GOA
Biological Process GO Annotation Evidence References Source
involved in Roundabout signaling pathway IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in apoptotic process involved in luteolysis IEP
IEP: Inferred from expression pattern
18566128 GOA
involved in axon extension involved in axon guidance IDA
IDA: Inferred from direct assay
16840550 GOA
involved in axon guidance IDA
IDA: Inferred from direct assay
11748139 GOA
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
18566128 GOA
NOT involved in chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration IDA
IDA: Inferred from direct assay
11748139 GOA
involved in negative chemotaxis IDA
IDA: Inferred from direct assay
11748139 GOA
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in negative regulation of chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18829537 GOA
involved in response to cortisol IEP
IEP: Inferred from expression pattern
18566128 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
19741192 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLIT3 Protein Structure

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (33 - 60)

LRR_8

LRR_8: Leucine rich repeat (110 - 169)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (240 - 264)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (280 - 306)

LRR_8

LRR_8: Leucine rich repeat (332 - 391)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (462 - 486)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (505 - 531)

LRR_8

LRR_8: Leucine rich repeat (534 - 593)

LRR_8

LRR_8: Leucine rich repeat (606 - 664)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (687 - 712)

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (725 - 751)

LRR_8

LRR_8: Leucine rich repeat (799 - 859)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (882 - 906)

EGF

EGF: EGF-like domain (959 - 992)

EGF

EGF: EGF-like domain (1000 - 1029)

EGF

EGF: EGF-like domain (1038 - 1069)

EGF

EGF: EGF-like domain (1078 - 1107)

EGF

EGF: EGF-like domain (1124 - 1153)

Laminin_G_2

Laminin_G_2: Laminin G domain (1187 - 1314)

hEGF

hEGF: Human growth factor-like EGF (1352 - 1364)

EGF

EGF: EGF-like domain (1372 - 1400)

hEGF

hEGF: Human growth factor-like EGF (1432 - 1443)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1523 a.a.
Protein Preferred Names Protein Names

slit homolog 3 protein

  • multiple EGF-like domains protein 5

Related Diseases

Diseases Alias
Hepatic Adenomas, Familial

  • Hepatic Adenoma, Somatic

  • Familial Hepatic Adenoma

  • Familial Liver Cell Adenomas

  • Liver Cell Adenomas, Familial

  • Hepatic Adenomas Familial

  • HEPAF

  • Ha

  • Hepatocellular Adenomas

  • Hepatocellular Adenoma
Diaphragm Disease

  • Abnormality Of The Diaphragm

  • Disease Of Diaphragm

  • Diaphragmatic Disorder

  • Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13370 SLIT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13372 SLIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20490 Slit3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26998 Slit3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLIT3 VGNC VGNC:34961
Canis familiaris SLIT3 VGNC VGNC:46505
Rattus norvegicus SLIT3 RGD RGD:69311
Mus musculus SLIT3 MGD MGI:1315202
Macaca mulatta SLIT3 VGNC VGNC:77645
Felis catus SLIT3 VGNC VGNC:65453
Others SLIT3 NCBI