BPHL - biphenyl hydrolase like Gene

Also Known as MCNAA; BPH-RP; VACVASE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 670

About BPHL

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:3,118,376-3,153,578 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in kidney (RPKM 36.5), liver (RPKM 16.0) and 19 other tissues.

Summary

This gene encodes a member of the serine protease family of hydrolytic Enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the Antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

BPHL Products (2)

mRNA Protein Name
NM_001302777.1 NP_001289706.1 valacyclovir hydrolase isoform 2
NM_004332.4 NP_004323.2 valacyclovir hydrolase isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables alpha-amino-acid esterase activity IDA
IDA: Inferred from direct assay
18256025 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BPHL Protein Structure

Abhydrolase_6

Abhydrolase_6: Alpha/beta hydrolase family (63 - 284)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

valacyclovir hydrolase

  • biphenyl hydrolase-like (serine hydrolase)

Recombinant BPHL Proteins

Cat. No. Product Name Accession Purity
HY-P71838 BPHL Protein, Human (P.pastoris, His-Myc) Q86WA6-1 (S38-Q291) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76177 BPHL Protein, Human (His) Q86WA6-1 (S38-Q291) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cardiomyopathy, Dilated, 1m

  • Dilated Cardiomyopathy 1m

  • CMD1M

  • Cardiomyopathy, Dilated 1m

  • Cardiomyopathy, Dilated, Type 1m
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01579 BPHL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18231 Bphl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24710 Bphl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BPHL VGNC VGNC:53958
Rattus norvegicus BPHL RGD RGD:1307572
Mus musculus BPHL MGD MGI:1915271
Canis familiaris BPHL VGNC VGNC:38503
Macaca mulatta BPHL VGNC VGNC:70276
Others BPHL NCBI