BPHL - biphenyl hydrolase like Gene

Homo sapiens

Also known as MCNAA; BPH-RP; VACVASE

Gene ID: 670 | Gene type: protein coding

About BPHL

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:3,118,376-3,153,578 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 12 paralogues. Broad expression in kidney (RPKM 36.5), liver (RPKM 16.0) and 19 other tissues.

Summary

This gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the Antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]

BPHL Products(2)

mRNA	Protein	Name
NM_001302777.1	NP_001289706.1	valacyclovir hydrolase isoform 2
NM_004332.4	NP_004323.2	valacyclovir hydrolase isoform 1 precursor

BPHL Protein Structure

Abhydrolase_6

0
100
200
291 a.a.

Protein Preferred Names

Protein Names

valacyclovir hydrolase

biphenyl hydrolase-like (serine hydrolase)

Recombinant BPHL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71838	BPHL Protein, Human (P.pastoris, His-Myc)	Q86WA6 (38S-291Q)	≥95%
HY-P76177	BPHL Protein, Human (His)	Q86WA6-1 (S38-Q291)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m	CMD1M
Cardiomyopathy, Dilated 1m	Cardiomyopathy, Dilated, Type 1m

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01579	BPHL Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BPHL	VGNC	VGNC:53958
Rattus norvegicus	BPHL	RGD	RGD:1307572
Mus musculus	BPHL	MGD	MGI:1915271
Canis familiaris	BPHL	VGNC	VGNC:38503
Macaca mulatta	BPHL	VGNC	VGNC:70276
Others	BPHL	NCBI