Ndc80 - NDC80 kinetochore complex component Gene

Also Known as HEC; HEC1; Kntc2; 2610020P18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67052

Summary

Enables cyclin binding activity. Acts upstream of or within kinetochore organization; meiosis I cell cycle process; and regulation of protein stability. Located in centrosome; cytoplasm; and kinetochore. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Apr 2022]

Ndc80 Products (1)

mRNA Protein Name
NM_023294.2 NP_075783.2 kinetochore protein NDC80 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cyclin binding IPI
IPI: Inferred from physical interaction
23541922 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11591653 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G2/MI transition of meiotic cell cycle IDA
IDA: Inferred from direct assay
23541922 MGI
acts upstream of or within kinetochore organization IMP
IMP: Inferred from mutant phenotype
23541922 MGI
acts upstream of or within mitotic cell cycle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
18940925 MGI
acts upstream of or within regulation of protein stability IMP
IMP: Inferred from mutant phenotype
23541922 MGI
acts upstream of or within skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
32483152 MGI
acts upstream of or within spindle assembly involved in female meiosis I IGI
IGI: Inferred from genetic interaction
23541922 MGI
acts upstream of or within spindle assembly involved in female meiosis I IMP
IMP: Inferred from mutant phenotype
23541922 MGI
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
18940925 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23541922 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
18940925 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinetochore protein NDC80 homolog

  • NDC80 homolog, kinetochore complex component

  • highly expressed in cancer, rich in leucine heptad repeats

  • kinetochore associated 2

  • kinetochore protein Hec1

  • kinetochore-associated protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09105 NDC80 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19722 Ndc80 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26218 Ndc80 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndc80 NCBI NCBI:10403