BST1 - bone marrow stromal cell antigen 1 Gene

Also Known as CD157; cADPR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 683

About BST1

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:15,703,065-15,774,173 (from NCBI)

This gene has 5 transcripts (splice variants), 117 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.1), duodenum (RPKM 6.3) and 23 other tissues.

Summary

Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

BST1 Products (1)

mRNA	Protein	Name
NM_004334.3	NP_004325.2	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IDA IDA: Inferred from direct assay	7805847	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	8202488	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	15328157	GOA
involved in regulation of cell-matrix adhesion	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of inflammatory response	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of neutrophil chemotaxis	IDA IDA: Inferred from direct assay	15328157	GOA
involved in regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8941363	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	8202488	GOA
located in uropod	IDA IDA: Inferred from direct assay	15328157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BST1 Protein Structure

Rib_hydrolayse

0
100
200
300
318 a.a.

Protein Preferred Names	Protein Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2	ADP-ribosyl cyclase 2

Recombinant BST1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7791	CD157 Protein, Human (HEK293, His)	Q10588 (G29-K292)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7792	CD157 Protein, Human (HEK293, Fc)	Q10588 (G29-K292)	≥ 95%, as determined by reducing SDS-PAGE.

BST1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84516	CD157 Antibody (YA4213)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
HY-P84516A	CD157 Antibody (YA4213)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Paroxysmal Nocturnal Hemoglobinuria	Marchiafava-Micheli Disease Pnh Hemoglobinuria, Paroxysmal Marchiafava-Micheli Syndrome Paroxysmal Hemoglobinuria Nocturnal Nocturnal Haemoglobinuria Nocturnal Paroxysmal Haematuria Nocturnal Paroxysmal Haemoglobinaemia
Rem Sleep Behavior Disorder	Rapid Eye Movement Sleep Behavior Disorder Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Hemoglobinuria
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991665	MEN1112	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01648	BST1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10377	PGAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17739	Bst1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24204	Bst1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991884	Anti-BST1 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BST1	MGD	MGI:105370
Rattus norvegicus	BST1	RGD	RGD:620344
Felis catus	BST1	VGNC	VGNC:60191
Macaca mulatta	BST1	VGNC	VGNC:70285
Canis familiaris	BST1	VGNC	VGNC:38541
Bos taurus	BST1	VGNC	VGNC:26581
Others	BST1	NCBI