Sirt5 - sirtuin 5 Gene

Also Known as 0610012J09Rik; 1500032M05Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68346

About Sirt5

Chromosome 13: 43,518,972-43,548,679 forward strand.GRCm39:CM001006.3

This gene has 11 transcripts (splice variants), 265 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues.

Summary

Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of Succinate Dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (Sirtuin 5). [provided by Alliance of Genome Resources, Apr 2022]

Sirt5 Products (1)

mRNA	Protein	Name
NM_178848.3	NP_849179.1	NAD-dependent protein deacylase sirtuin-5, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19410549	MGI
enables protein-glutaryllysine deglutarylase activity	IDA IDA: Inferred from direct assay	24703693	MGI
enables protein-malonyllysine demalonylase activity	IDA IDA: Inferred from direct assay	24703693	MGI
enables protein-malonyllysine demalonylase activity	IMP IMP: Inferred from mutant phenotype	21908771	MGI
enables protein-succinyllysine desuccinylase activity	IDA IDA: Inferred from direct assay	24703693	MGI
enables protein-succinyllysine desuccinylase activity	IMP IMP: Inferred from mutant phenotype	21908771	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in peptidyl-lysine demalonylation	IMP IMP: Inferred from mutant phenotype	21908771	MGI
acts upstream of or within peptidyl-lysine desuccinylation	IMP IMP: Inferred from mutant phenotype	26388266	MGI
involved in peptidyl-lysine desuccinylation	IMP IMP: Inferred from mutant phenotype	21908771	MGI
involved in protein deglutarylation	IDA IDA: Inferred from direct assay	24703693	MGI
involved in protein demalonylation	IDA IDA: Inferred from direct assay	24703693	MGI
involved in protein desuccinylation	IDA IDA: Inferred from direct assay	24703693	MGI
involved in protein desuccinylation	IMP IMP: Inferred from mutant phenotype	23806337	MGI
involved in regulation of ketone biosynthetic process	IMP IMP: Inferred from mutant phenotype	24315375	MGI
acts upstream of or within regulation of succinate dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	26388266	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	26388266	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	23806337	MGI
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	18054327	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	17923681	MGI
is active in mitochondrion	IMP IMP: Inferred from mutant phenotype	26388266	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sirt5 Protein Structure

SIRT5_Af1_CobB

0
100
200
310 a.a.

Protein Preferred Names	Protein Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial	NAD-dependent deacetylase sirtuin-5 NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial

Sirt5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Sirt5	Q8K2C6	Cps1	Mus musculus	Q8C196	Anti Tag CoIP	19410549

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0879A	Suramin sodium salt	Inhibitor	99.98%	Yes
HY-B0879	Suramin	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145651	Et-29	Inhibitor	99.89%	Unkown
HY-146387	SIRT5 inhibitor 3	Inhibitor	98.0%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	98.37%	Unkown
HY-168681	Sirtuin-IN-2	Inhibitor	/	Unkown
HY-152214	SIRT5 inhibitor 5	Inhibitor	/	Unkown
HY-184000	SIRT5-IN-10	Inhibitor	/	Unkown
HY-146386	SIRT5 inhibitor 2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt5	NCBI	NCBI:23408