Steap3 - STEAP family member 3 Gene

Also Known as Tsap6; pHyde; 1010001D01Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68428

Summary

Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within exosomal secretion; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including bone; genitourinary system; liver; nervous system; and white fat. Orthologous to human STEAP3 (STEAP3 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]

Steap3 Products (4)

mRNA	Protein	Name
NM_001085409.2	NP_001078878.1	metalloreductase STEAP3 isoform b
NM_001379354.1	NP_001366283.1	metalloreductase STEAP3 isoform b
NM_001379355.1	NP_001366284.1	metalloreductase STEAP3 isoform a
NM_133186.4	NP_573449.2	metalloreductase STEAP3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cupric reductase (NADH) activity	IDA IDA: Inferred from direct assay	16609065	MGI
enables ferric-chelate reductase (NADPH) activity	IDA IDA: Inferred from direct assay	16609065	MGI
enables ferric-chelate reductase (NADPH) activity	IMP IMP: Inferred from mutant phenotype	18955558	MGI
enables ferric-chelate reductase activity	IDA IDA: Inferred from direct assay	16227996	MGI
enables ferric-chelate reductase activity	IMP IMP: Inferred from mutant phenotype	16227996	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26642240	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within copper ion import	IDA IDA: Inferred from direct assay	16609065	MGI
acts upstream of or within copper ion import	IMP IMP: Inferred from mutant phenotype	18955558	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	16227996	MGI
acts upstream of or within exosomal secretion	IMP IMP: Inferred from mutant phenotype	18617898	MGI
acts upstream of or within iron import into cell	IDA IDA: Inferred from direct assay	16609065	MGI
acts upstream of or within iron ion import across cell outer membrane	IDA IDA: Inferred from direct assay	16609065	MGI
acts upstream of or within iron ion import across cell outer membrane	IMP IMP: Inferred from mutant phenotype	18955558	MGI
acts upstream of or within iron ion transport	IMP IMP: Inferred from mutant phenotype	16227996	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	18617898	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endosome	IDA IDA: Inferred from direct assay	16227996	MGI
located in endosome membrane	IMP IMP: Inferred from mutant phenotype	18955558	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16227996	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
metalloreductase STEAP3	dudulin 2 protein nm1054 six-transmembrane epithelial antigen of prostate 3 tumor suppressor-activated pathway protein 6

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13908	STEAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17857	Steap3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24326	Steap3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Steap3	NCBI	NCBI:55240