SYCP1 - synaptonemal complex protein 1 Gene

Homo sapiens

Also known as CT8; SCP1; SCP-1; HOM-TES-14

Gene ID: 6847 | Gene type: protein coding

About SYCP1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,854,088-114,995,370 (from NCBI)

This gene has 10 transcripts (splice variants) and 181 orthologues. Restricted expression toward testis (RPKM 18.8).

Summary

Enables double-stranded DNA binding activity. Involved in protein homotetramerization. Predicted to be located in synaptonemal complex. Predicted to be active in central element; male germ cell nucleus; and transverse filament. [provided by Alliance of Genome Resources, Apr 2022]

SYCP1 Products(3)

mRNA	Protein	Name
NM_001282541.2	NP_001269470.1	synaptonemal complex protein 1 isoform 1
NM_001282542.2	NP_001269471.1	synaptonemal complex protein 1 isoform 2
NM_003176.4	NP_003167.2	synaptonemal complex protein 1 isoform 1

SYCP1 Protein Structure

SCP-1

0
200
400
600
800
976 a.a.

Protein Preferred Names

Protein Names

synaptonemal complex protein 1

cancer/testis antigen 8

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Infertility

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14070	SYCP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SYCP1	VGNC	VGNC:35508
Canis familiaris	SYCP1	VGNC	VGNC:47018
Mus musculus	SYCP1	MGD	MGI:105931
Macaca mulatta	SYCP1	VGNC	VGNC:78062
Felis catus	SYCP1	VGNC	VGNC:80371
Rattus norvegicus	SYCP1	RGD	RGD:3794

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