TEAD3 - TEA domain transcription factor 3 Gene

Also Known as TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7005

About TEAD3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,473,597-35,497,079 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 22.4), endometrium (RPKM 21.2) and 23 other tissues.

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

TEAD3 Products (2)

mRNA Protein Name
NM_001395214.1 NP_001382143.1 transcriptional enhancer factor TEF-5 isoform 2
NM_003214.4 NP_003205.2 transcriptional enhancer factor TEF-5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
18579750 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
23946438 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in asymmetric neuroblast division IGI
IGI: Inferred from genetic interaction
23946438 GOA
involved in hippo signaling IDA
IDA: Inferred from direct assay
18579750 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD3 Protein Structure

TEA

TEA: TEA/ATTS domain family (8 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
Protein Preferred Names Protein Names

transcriptional enhancer factor TEF-5

  • TEA domain family member 3

TEAD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Validated Y2H
25416956
Intra
TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Y2H Array
25416956
Intra
TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Y2H Prey Pooling
25416956
Intra
TEAD3 Q99594 VGLL1 Homo sapiens Q99990
Validated Y2H
32296183
Intra
TEAD3 Q99594 VGLL1 Homo sapiens Q99990
Y2H Array
20211142
Intra
TEAD3 Q99594 WWTR1 Homo sapiens Q9GZV5
Y2H Pooling
16189514
Intra
TEAD3 Q99594 WWTR1 Homo sapiens Q9GZV5
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TEAD3 Proteins

Cat. No. Product Name Accession Purity
HY-P71626 TEAD3 Protein, Human (His-SUMO) Q99594 (M112-D435) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Skin Carcinoma In Situ

  • Carcinoma In Situ Of Skin

  • Cutaneous Carcinoma In Situ
Sveinsson Chorioretinal Atrophy

  • SCRA

  • Atrophia Areata

  • Helicoid Peripapillary Chorioretinal Degeneration

  • Hpcd

  • Aa

  • Peripapillary Chorioretinal Degeneration, Icelandic Type

  • Helicoidal Peripapillary Chorioretinal Degeneration

  • Atrophy, Chorioretinal, Sveinsson
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-172113 H122 98.33% Phase 4

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134956 VT104 Inhibitor 99.94% Unkown
HY-147135 MYF-03-69 98.11% Unkown
HY-147136 MYF-03-176 Inhibitor 99.72% Unkown
HY-147208 MSC-4106 Inhibitor 99.87% Unkown
HY-163644 VT-105 Inhibitor 99.93% Unkown
HY-161569 TEAD-IN-11 Inhibitor 99.82% Unkown
HY-186117 KG-FP-003 Degrader / Unkown
HY-147209 DC-TEAD3in03 Inhibitor / Unkown
HY-161568 TEAD-IN-10 Inhibitor / Unkown
HY-170764 M3686 Inhibitor / Unkown
HY-173139 TEAD-IN-19 Inhibitor / Unkown
HY-181534 PROTAC TEAD1/IAP degrader-1 Degrader / Unkown
HY-182672 VT101 Inhibitor / Unkown
HY-183753 LC-TD-05 / Unkown
HY-184225 PROTAC TEAD degrader-3 Degrader / Unkown
HY-185230 HC278 Degrader / Unkown
HY-186118 TEAD ligand 6 Ligand / Unkown
HY-RS14344 TEAD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18299 Tead3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24777 Tead3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TEAD3 RGD RGD:1311583
Mus musculus TEAD3 MGD MGI:109241
Bos taurus TEAD3 VGNC VGNC:35726
Macaca mulatta TEAD3 VGNC VGNC:78303
Felis catus TEAD3 VGNC VGNC:66055
Canis familiaris TEAD3 VGNC VGNC:47230
Others TEAD3 NCBI