Tmem106b - transmembrane protein 106B Gene

Also Known as 2310036D22Rik; 5830455K21Rik; 6430519M21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71900

Summary

Enables ATPase binding activity. Acts upstream of or within several processes, including lysosomal lumen acidification; lysosomal protein catabolic process; and positive regulation of dendrite development. Located in lysosome. Is expressed in several structures, including alimentary system; hemolymphoid system gland; integumental system; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human TMEM106B (transmembrane protein 106B). [provided by Alliance of Genome Resources, Apr 2022]

Tmem106b Products (1)

mRNA Protein Name
NM_027992.3 NP_082268.2 transmembrane protein 106B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
28728022 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lysosomal lumen acidification IMP
IMP: Inferred from mutant phenotype
28728022 MGI
acts upstream of or within lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
28728022 MGI
acts upstream of or within lysosomal transport IMP
IMP: Inferred from mutant phenotype
25066864 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
25066864 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
28728022 MGI
acts upstream of or within positive regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
25066864 MGI
acts upstream of or within positive regulation of hydrolase activity IMP
IMP: Inferred from mutant phenotype
28728022 MGI
acts upstream of or within regulation of lysosome organization IMP
IMP: Inferred from mutant phenotype
28728022 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
25066864 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein 106B

Recombinant Tmem106b Proteins

Cat. No. Product Name Accession Purity
HY-P77854 TMEM106B Protein, Mouse (HEK293, Fc) Q80X71 (P119-Q275) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14646 TMEM106B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20232 Tmem106b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26739 Tmem106b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmem106b NCBI NCBI:54664