Ercc8 - excision repaiross-complementing rodent repair deficiency, complementation group 8 Gene

Also Known as Csa; Ckn1; 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71991

Summary

Predicted to contribute to ubiquitin-protein transferase activity. Acts upstream of or within response to UV and response to X-ray. Predicted to be located in cytoplasm; nuclear matrix; and perikaryon. Predicted to be part of Cul4A-RING E3 ubiquitin Ligase complex and nucleotide-excision repair complex. Used to study Cockayne syndrome. Human ortholog(s) of this gene implicated in Cockayne syndrome; Cockayne syndrome A; and UV-sensitive syndrome. Orthologous to human ERCC8 (ERCC excision repair 8, CSA ubiquitin Ligase complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc8 Products (2)

mRNA Protein Name
NM_001362403.1 NP_001349332.1 DNA excision repair protein ERCC-8 isoform 2
NM_028042.4 NP_082318.2 DNA excision repair protein ERCC-8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
15340056 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
17145777 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA excision repair protein ERCC-8

  • Cockayne syndrome 1 homolog

  • cockayne syndrome WD repeat protein CSA homolog

Ercc8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ercc8 Q8CFD5 Ssbp4 Mus musculus Q3U4B1
Y2H Array
20211142
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04486 ERCC8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22492 Ercc8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29015 Ercc8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc8 NCBI NCBI:1161