TRO - trophinin Gene

Also Known as MAGED3; MAGE-d3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7216

About TRO

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:54,920,824-54,931,431 (from NCBI)

This gene has 25 transcripts (splice variants), 162 orthologues and 37 paralogues. Broad expression in ovary (RPKM 9.7), brain (RPKM 9.7) and 20 other tissues.

Summary

This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in Cancer formation. This gene is located near several Other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

TRO Products (6)

mRNA Protein Name
NM_001039705.3 NP_001034794.1 trophinin isoform 5
NM_001271183.2 NP_001258112.1 trophinin isoform 6
NM_001271184.2 NP_001258113.1 trophinin isoform 7
NM_016157.4 NP_057241.2 trophinin isoform 2
NM_177556.3 NP_808224.1 trophinin isoform 2
NM_177557.3 NP_808225.1 trophinin isoform 4

TRO Protein Structure

MAGE

MAGE: MAGE family (451 - 620)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1431 a.a.
Protein Preferred Names Protein Names

trophinin

  • MAGE superfamily protein

Related Diseases

Diseases Alias
Ectopic Pregnancy

  • Eccyesis

  • Pregnancy Ectopic

  • Pregnancy, Ectopic

  • Ectopic Pregnancies

  • Extrauterine Gestation Or Pregnancy

  • Extrauterine Pregnancy

  • Ep - [Ectopic Pregnancy]

  • Ectopic Mole

  • Aborted Ectopic Pregnancy

  • Ruptured Ectopic Pregnancy
Dysbaric Osteonecrosis

  • Caisson Disease Of Bone

  • Don
Crouzon Syndrome With Acanthosis Nigricans

  • Crouzon Syndrome-Acanthosis Nigricans Syndrome

  • CAN

  • Crouzonodermoskeletal Syndrome

  • Crouzon-Dermoskeletal Syndrome

  • Crouzon, With Acanthosis Nigricans Syndrome
Hermansky-Pudlak Syndrome 3

  • HPS3

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 3

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Secondary Syphilis

  • Syphilis, Secondary

  • Secondary Syphilis Of Viscera Or Bone
Prader-Willi Syndrome

  • Prader-Labhart-Willi Syndrome

  • PWS

  • Willi-Prader Syndrome

  • Prader-Willi Syndrome Due To Translocation

  • Prader-Willi Syndrome Due To Imprinting Mutation

  • Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

  • Prader Willi Syndrome

  • Upd(15)Mat
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-14796 Olesoxime Inhibitor 99.04% Phase 3
HY-19854 TRO-40303 / Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-154848 UCL-TRO-1938 Activator 99.98% Unkown
HY-RS15100 TRO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17047 Tro Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23491 Tro Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRO MGD MGI:1928994
Rattus norvegicus TRO RGD RGD:6488256
Bos taurus TRO VGNC VGNC:108180
Others TRO NCBI