Tppp - tubulin polymerization promoting protein Gene

Also Known as TPPP/p25; 2900041A09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72948

Summary

Predicted to enable several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in microtubule polymerization; nervous system development; and positive regulation of myelination. Located in cytoplasm and nucleus. Colocalizes with microtubule. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and nasal cavity epithelium. Orthologous to human TPPP (tubulin polymerization promoting protein). [provided by Alliance of Genome Resources, Apr 2022]

Tppp Products (1)

mRNA Protein Name
NM_182839.2 NP_878259.1 tubulin polymerization-promoting protein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in microtubule polymerization IDA
IDA: Inferred from direct assay
18028908 MGI
involved in myelin assembly IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
31522887 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
31522887 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18028908 MGI
colocalizes with microtubule IDA
IDA: Inferred from direct assay
18028908 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18028908 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tubulin polymerization-promoting protein

  • 25 kDa brain-specific protein

  • brain-specific protein p25 alpha

  • p25-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14944 TPPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14945 TPPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19391 Tppp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19487 Tppp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25883 Tppp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25981 Tppp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tppp NCBI NCBI:11076