Steap2 - six transmembrane epithelial antigen of prostate 2 Gene

Also Known as STMP; IPCA1; IPCA-1; STAMP1; PCANAP1; 4921538B17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74051

Summary

Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within copper ion import across plasma membrane; iron ion import across cell outer membrane; and iron ion import across plasma membrane. Located in endosome and plasma membrane. Is expressed in several structures, including brain; gut; metanephros; reproductive system; and respiratory system. Orthologous to human STEAP2 (STEAP2 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]

Steap2 Products (6)

mRNA Protein Name
NM_001103156.2 NP_001096626.1 metalloreductase STEAP2 isoform 1
NM_001103157.2 NP_001096627.1 metalloreductase STEAP2 isoform 1
NM_001285469.1 NP_001272398.1 metalloreductase STEAP2 isoform 1
NM_001285470.1 NP_001272399.1 metalloreductase STEAP2 isoform 1
NM_001285471.1 NP_001272400.1 metalloreductase STEAP2 isoform 2
NM_028734.5 NP_083010.2 metalloreductase STEAP2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cupric reductase (NADH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
enables ferric-chelate reductase (NADPH) activity IDA
IDA: Inferred from direct assay
16609065 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within copper ion import IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within copper ion import across plasma membrane IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within iron ion import across cell outer membrane IDA
IDA: Inferred from direct assay
16609065 MGI
acts upstream of or within iron ion import across plasma membrane IDA
IDA: Inferred from direct assay
16609065 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
16609065 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16609065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metalloreductase STEAP2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173639 AZD0516 99.15% Unkown
HY-RS13907 STEAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21200 Steap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27716 Steap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991503 Anti-STEAP2 Antibody 99.65% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Steap2 NCBI NCBI:261729