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Atg7 - autophagy related 7 Gene

Also Known as Agp7; Apg7l; Atg7l; Gm21553; 1810013K23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74244

Summary

This gene encodes an E1-like activating enzyme that is essential for Autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, Mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Atg7 Products (4)

mRNA	Protein	Name
NM_001253717.2	NP_001240646.1	ubiquitin-like modifier-activating enzyme ATG7 isoform 1
NM_001253718.2	NP_001240647.1	ubiquitin-like modifier-activating enzyme ATG7 isoform 2
NM_001379130.1	NP_001366059.1	ubiquitin-like modifier-activating enzyme ATG7 isoform 3
NM_028835.5	NP_083111.1	ubiquitin-like modifier-activating enzyme ATG7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Atg12 activating enzyme activity	IDA IDA: Inferred from direct assay	11890701	MGI
enables Atg12 activating enzyme activity	IMP IMP: Inferred from mutant phenotype	20723759	MGI
enables Atg8 activating enzyme activity	IDA IDA: Inferred from direct assay	11890701	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11890701	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of or within autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23704209	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	20080761	MGI
acts upstream of or within autophagy	IMP IMP: Inferred from mutant phenotype	15866887	MGI
involved in autophagy	IMP IMP: Inferred from mutant phenotype	20080761	MGI
acts upstream of or within autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	23981124	MGI
acts upstream of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	23981124	MGI
acts upstream of or within cellular response to starvation	IMP IMP: Inferred from mutant phenotype	22496425	MGI
acts upstream of or within central nervous system neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	20577052	MGI
acts upstream of or within cerebellar Purkinje cell layer development	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of positive effect chromatin organization	IMP IMP: Inferred from mutant phenotype	23863932	MGI
acts upstream of or within defense response to virus	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within innate immune response	IMP IMP: Inferred from mutant phenotype	26764600	MGI
acts upstream of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24105478	MGI
acts upstream of or within intracellular amino acid homeostasis	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within intracellular sphingolipid homeostasis	IMP IMP: Inferred from mutant phenotype	25332431	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within macroautophagy	IMP IMP: Inferred from mutant phenotype	22496425	MGI
acts upstream of or within membrane organization	IMP IMP: Inferred from mutant phenotype	17726112	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	21402742	MGI
involved in mitophagy	IMP IMP: Inferred from mutant phenotype	20080761	MGI
acts upstream of mucus secretion	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16625205	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20080761	MGI
acts upstream of or within negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17450150	MGI
acts upstream of or within negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	24035364	MGI
acts upstream of or within negative regulation of sphingolipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25332431	MGI
acts upstream of or within negative regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24105478	MGI
acts upstream of or within negative stranded viral RNA replication	IMP IMP: Inferred from mutant phenotype	24550300	MGI
acts upstream of or within nervous system process	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of or within neuron projection development	IMP IMP: Inferred from mutant phenotype	17726112	MGI
acts upstream of or within organelle organization	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	24105478	MGI
acts upstream of or within positive regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	24185898	MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	23152632	MGI
acts upstream of or within positive regulation of protein modification process	IDA IDA: Inferred from direct assay	12482611	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within protein modification by small protein conjugation	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of or within pyramidal neuron development	IMP IMP: Inferred from mutant phenotype	16625205	MGI
involved in regulation of cell development	IMP IMP: Inferred from mutant phenotype	20080761	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	29937374	MGI
involved in regulation of hemopoiesis	IMP IMP: Inferred from mutant phenotype	20080761	MGI
acts upstream of or within regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	16625205	MGI
acts upstream of or within response to starvation	IMP IMP: Inferred from mutant phenotype	15866887	MGI
acts upstream of sphingolipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	25332431	MGI
involved in synaptic vesicle cycle	IDA IDA: Inferred from direct assay	22542182	MGI
involved in synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	22542182	MGI
acts upstream of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24105478	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axoneme	IDA IDA: Inferred from direct assay	24089209	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	22542182	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	22542182	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14627652	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ubiquitin-like modifier-activating enzyme ATG7	ATG12-activating enzyme E1 ATG7 autophagy-related protein 7 ubiquitin-activating enzyme E1-like protein

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0538	Xylitol	Activator	99.5%	Yes

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-146130	ATG7-IN-2		99.32%	Unkown
HY-145371	ATG7-IN-1	Inhibitor	99.84%	Unkown
HY-146131	ATG7-IN-3		99.26%	Unkown
HY-N13352	Bufothionine	Activator	/	Unkown
HY-151914	Antitumor agent-82		/	Unkown
HY-173133	Antitumor agent-199	Activator	/	Unkown
HY-170594	Antitumor agent-192		/	Unkown
HY-W768347	Xylitol-13C5		/	Unkown
HY-179052	Apoptosis inducer 50	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atg7	NCBI	NCBI:10533