Usp50 - ubiquitin specific peptidase 50 Gene

Also Known as 1700086G18Rik; 4930511O11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75083

Summary

Predicted to enable thiol-dependent Deubiquitinase. Acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly and positive regulation of macromolecule metabolic process. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Predicted to be extrinsic component of endosome membrane and extrinsic component of plasma membrane. Orthologous to human USP50 (ubiquitin specific peptidase 50). [provided by Alliance of Genome Resources, Apr 2022]

Usp50 Products (1)

mRNA Protein Name
NM_029163.3 NP_083439.2 putative ubiquitin carboxyl-terminal hydrolase 50

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28094437 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of NLRP3 inflammasome complex assembly IMP
IMP: Inferred from mutant phenotype
28094437 MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
28094437 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
28094437 MGI
acts upstream of or within positive regulation of interleukin-18 production IMP
IMP: Inferred from mutant phenotype
28094437 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

putative ubiquitin carboxyl-terminal hydrolase 50

  • deubiquitinating enzyme 50

  • ubiquitin specific protease 50

  • ubiquitin thioesterase 50

  • ubiquitin thiolesterase 50

  • ubiquitin-specific-processing protease 50

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15562 USP50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22904 Usp50 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29418 Usp50 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp50 NCBI NCBI:373509