CA11 - carbonic anhydrase 11 Gene

Homo sapiens

Also known as CA-RP; CA-XI; CARP-2; CARPX1; CA-RP II

Gene ID: 770 | Gene type: protein coding

About CA11

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,637,946-48,646,187 (from NCBI)

This gene has 4 transcripts (splice variants), 264 orthologues and 14 paralogues. Biased expression in brain (RPKM 69.9), ovary (RPKM 14.7) and 2 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has Carbonic Anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

CA11 Products(1)

mRNA	Protein	Name
NM_001217.5	NP_001208.2	carbonic anhydrase-related protein 11 precursor

CA11 Protein Structure

Carb_anhydrase

0
100
200
300
328 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase-related protein 11

carbonic anhydrase XI

Recombinant CA11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7729	Carbonic Anhydrase 11 Protein, Human (HEK293, His)	O75493 (V64-R328)	≥95%

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01764	CA11 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CA11	VGNC	VGNC:60241
Canis familiaris	CA11	VGNC	VGNC:38606
Rattus norvegicus	CA11	RGD	RGD:735155
Mus musculus	CA11	MGD	MGI:1336193
Macaca mulatta	CA11	VGNC	VGNC:70487
Bos taurus	CA11	VGNC	VGNC:26649
Others	CA11	NCBI