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Fgfr1 - Fibroblast growth factor receptor 1 Gene

Also Known as MFR; c-fgr; FGFR-1; bFGF-R; bFGF-R-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 79114

About Fgfr1

Primary_assembly 16: 66,494,042-66,547,350 reverse strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 292 orthologues, 54 paralogues and is associated with 87 phenotypes. Biased expression in Kidney (RPKM 185.8), Lung (RPKM 166.8) and 9 other tissues.

Summary

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; sciatic neuropathy; vascular dementia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic Cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (Fibroblast Growth Factor receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr1 Products (1)

mRNA	Protein	Name
NM_024146.2	NP_077060.2	fibroblast growth factor receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	19666467	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15117958	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	19339244	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	25485703	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to histamine	IEP IEP: Inferred from expression pattern	23497494	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	30250515	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	9011767	RGD
involved in central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	17314281	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	7789341	RGD
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	18690792	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	12791257	RGD
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18275970	RGD
involved in positive regulation of fibroblast migration	IMP IMP: Inferred from mutant phenotype	12176960	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	30250515	RGD
involved in positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18690792	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	22035699	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19229075	RGD
involved in postnatal olfactory bulb interneuron migration	IMP IMP: Inferred from mutant phenotype	20083104	RGD
involved in regulation of cell population proliferation	IDA IDA: Inferred from direct assay	9763444	RGD
involved in regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18690792	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	10521571	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21430024	RGD
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19505325	RGD
involved in tangential migration from the subventricular zone to the olfactory bulb	IMP IMP: Inferred from mutant phenotype	20083104	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10670490	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr1 Protein Structure

IgI_1_FGFR

IgI_2_FGFR

PTKc_FGFR1

0
200
400
600
822 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 1	FGF receptor-1 basic fibroblast growth factor receptor 1 proto-oncogene c-Fgr

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99930	Efruxifermin	Activator	98.58%	Phase 3

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163705	BR-cpd7	Degrader	98.01%	Unkown
HY-165298	DGY-09-192	Degrader	99.50%	Unkown
HY-184094	Risimtinib	Inhibitor	/	Unkown
HY-135435	SU10944	Inhibitor	/	Unkown
HY-P11852	NOTA-cRY9M		/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-181752	FGFR3-IN-12	Inhibitor	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown
HY-184598	CYB-5067	Degrader	/	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990252	Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr1	NCBI	NCBI:2260