Aco2 - aconitase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79250

Summary

Enables 3 iron, 4 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and aconitate hydratase activity. Involved in several processes, including response to isolation stress; tricarboxylic acid cycle; and tricarboxylic acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in infantile cerebellar-retinal degeneration and optic atrophy 9. Orthologous to human ACO2 (aconitase 2). [provided by Alliance of Genome Resources, Apr 2022]

Aco2 Products (1)

mRNA Protein Name
NM_024398.2 NP_077374.2 aconitate hydratase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 3 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
14674759 RGD
enables 4 iron, 4 sulfur cluster binding IDA
IDA: Inferred from direct assay
14674759 RGD
enables aconitate hydratase activity IDA
IDA: Inferred from direct assay
9712727 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15840721 RGD
Biological Process GO Annotation Evidence References Source
involved in citrate metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in isocitrate metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
755797 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
19616040 RGD
involved in tricarboxylic acid cycle IDA
IDA: Inferred from direct assay
9712727 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aconitate hydratase, mitochondrial

  • aconitase 2, mitochondrial

  • citrate hydro-lyase

  • mitochondrial aconitase (nuclear aco2 gene)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00171 ACO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18460 Aco2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24941 Aco2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aco2 NCBI NCBI:50