CALB2 - calbindin 2 Gene
Also Known as CR; CAL2; CAB29
Species: Homo sapiens
About CALB2
This gene has 5 transcripts (splice variants), 1 gene allele, 268 orthologues and 2 paralogues. Biased expression in fat (RPKM 72.8), testis (RPKM 20.4) and 4 other tissues.
Summary
This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
CALB2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001740.5 | NP_001731.2 | calretinin isoform 1 |
| NM_007088.4 | NP_009019.1 | calretinin isoform 22k |
CALB2 Protein Structure
EF-hand_7: EF-hand domain pair (22 - 91)
EF-hand_7: EF-hand domain pair (113 - 178)
EF-hand_6: EF-hand domain (199 - 225)
- 0
- 100
- 200
- 271 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
calretinin |
|
CALB2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P810306 | Biotin Antibody | WB, IHC-P, IHC-F, ICC/IF, ELISA | Species independent |
| HY-P82591 | Calretinin Antibody (YA2336) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P82591A | Calretinin Antibody (YA2336)(PBS only) | WB, IHC-P, ICC/IF, FC | Human, Mouse, Rat |
| HY-P84191 | Calretinin Antibody (YA3888) | WB, FC, ELISA | Human, Monkey |
| HY-P84191A | Calretinin Antibody (YA3888)(PBS only) | WB, FC, ELISA | Human, Monkey |
| HY-P85942 | Calretinin Antibody (YA5634) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
| HY-P86833 | Calretinin Antibody (YA6526) | WB, IHC-P, IP, IF-Tissue | Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Adenomatoid Tumor |
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| Sertoli-Leydig Cell Tumor |
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| Sertoli Cell Tumor |
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| Leydig Cell Tumor |
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| Adenofibroma |
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| Benign Mesothelioma |
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| Sex Cord-Gonadal Stromal Tumor |
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| Granular Cell Tumor |
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| Malignant Pleural Mesothelioma |
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| Peritoneal Mesothelioma |
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| Asbestosis |
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| Sarcomatoid Mesothelioma |
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| Peritoneum Cancer |
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| Thymic Carcinoma |
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| Epithelioid Sarcoma |
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| Ameloblastoma |
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| Ovarian Benign Neoplasm |
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| Malignant Epithelial Mesothelioma |
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| Fallopian Tube Endometrioid Adenocarcinoma |
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| Malignant Biphasic Mesothelioma |
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| Fallopian Tube Adenocarcinoma |
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| Clear Cell Cystadenofibroma |
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| Spindle Cell Thymoma |
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| Epididymis Adenocarcinoma |
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| Ovarian Serous Cystadenofibroma |
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| Epididymis Cancer |
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| Ovarian Serous Adenofibroma |
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| Benign Peritoneal Mesothelioma |
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| Lung Leiomyosarcoma |
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| Mesothelioma, Malignant |
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| Peritoneal Serous Adenocarcinoma |
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| Cystadenoma |
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| Cervical Adenocarcinoma |
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| Pericardial Mesothelioma |
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| Ovarian Sex-Cord Stromal Tumor |
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| Fetal Alcohol Syndrome |
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| Pericardium Cancer |
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| Testicular Granulosa Cell Tumor |
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| Juvenile Type Testicular Granulosa Cell Tumor |
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| Pneumothorax |
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| Hematocele Of Tunica Vaginalis Testis |
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| Endosalpingiosis |
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| Epididymal Neoplasm |
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| Heart Cancer |
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| Adult Type Testicular Granulosa Cell Tumor |
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| Infected Hydrocele |
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| Benign Teratoma |
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| Lymphohistiocytoid Mesothelioma |
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| Sarcoma, Synovial |
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| Rete Testis Neoplasm |
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| Rete Testis Adenocarcinoma |
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| Wolffian Duct Adenocarcinoma |
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| Liposarcoma |
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| Glomus Tumor |
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| Rete Testis Adenoma |
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| Fibroma |
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| Ovarian Wilms' Cancer |
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| Carcinosarcoma |
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| Cystic Lymphangioma |
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| Spermatocele |
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| Salpingitis Isthmica Nodosa |
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| Colon Adenocarcinoma |
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| Testicular Fibroma |
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| Thymoma |
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| Papillary Carcinoma |
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| Myoblastoma |
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| Cystadenofibroma |
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| Benign Fibrous Mesothelioma |
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| Mixed Germ Cell-Sex Cord Neoplasm |
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| Luteoma |
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| Lung Sarcoma |
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| Fallopian Tube Carcinoma |
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| Status Epilepticus |
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| Adrenal Carcinoma |
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| Peritoneal Benign Neoplasm |
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| Medullary Colon Carcinoma |
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| Fallopian Tube Serous Adenocarcinoma |
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| Neurohypophysis Granular Cell Tumor |
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| Biphasic Synovial Sarcoma |
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| Fallopian Tube Carcinosarcoma |
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| Papillary Thymic Adenocarcinoma |
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| Cystic Teratoma |
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| Lung Sarcomatoid Carcinoma |
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| Angiosarcoma |
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| Endometriosis |
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| Pilar Sheath Acanthoma |
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| Large Cell Carcinoma With Rhabdoid Phenotype |
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| Pleural Cancer |
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| Myoma |
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| Pleural Lipoma |
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| Pacinian Tumor |
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| Papillary Serous Adenocarcinoma |
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| Myxoid Liposarcoma Of The Ovary |
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| Liposarcoma Of The Ovary |
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| Scrotum Neoplasm |
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| Pancreatic Mucinous Cystadenoma |
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| Constipation |
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| Breast Granular Cell Tumor |
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| Pheochromocytoma |
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| Thymus Sarcomatoid Carcinoma |
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| Malignant Glandular Tumor Of Peripheral Nerve Sheath |
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| Cervical Carcinosarcoma |
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| Adrenal Cortical Carcinoma |
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| Ovarian Germ Cell Teratoma |
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| Teratoma |
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| Paraganglioma |
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| Sarcoma |
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| Endometrial Cancer |
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| Middle Ear Carcinoma |
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| Cervix Endometriosis |
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| Hydrocele |
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| Monophasic Synovial Sarcoma |
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| Liver Fibroma |
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| Pleural Disease |
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| Neurilemmoma |
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| Ovarian Cancer |
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| Nephrogenic Adenoma Of The Urethra |
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| Ovarian Germ Cell Cancer |
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| Gallbladder Signet Ring Cell Adenocarcinoma |
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| Pericardial Tuberculosis |
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| Tuberculous Peritonitis |
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| Heart Sarcoma |
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| Pleomorphic Carcinoma |
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| Gastroesophageal Reflux |
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| Polycystic Liver Disease 1 With Or Without Kidney Cysts |
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| Krukenberg Carcinoma |
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| Hemangioma |
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| Endometrial Stromal Tumor |
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| Sigmoid Disease |
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| Schizophrenia |
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| Uterus Perivascular Epithelioid Cell Tumor |
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| Urethral Diverticulum |
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| Mixed Cell Type Cancer |
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| Kidney Hemangiopericytoma |
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| Megacolon |
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| Mediastinal Cancer |
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| Reproductive Organ Benign Neoplasm |
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| Articulation Disorder |
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| Serous Cystadenocarcinoma |
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| Major Depressive Disorder |
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| Constrictive Pericarditis |
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| Connective Tissue Benign Neoplasm |
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| Dysgerminoma Of Ovary |
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| Ovarian Small Cell Carcinoma |
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| Epilepsy |
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| Lung Cancer Susceptibility 3 |
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| Synovium Cancer |
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| Volvulus Of Midgut |
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| Urethral Benign Neoplasm |
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| Renal Cell Carcinoma, Nonpapillary |
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| Ovarian Gonadoblastoma |
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| Tuberculous Epididymitis |
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| Stuttering |
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| Epithelioid Cell Synovial Sarcoma |
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| Mediastinum Sarcoma |
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| Liver Leiomyoma |
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| Inguinal Hernia |
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| Huntington Disease |
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| Papillary Adenofibroma |
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| Dystonia |
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| Schizophrenia 12 |
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| Hirschsprung Disease 1 |
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| Lymphangioma |
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| Endometrial Stromal Sarcoma |
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| Testicular Disease |
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| Wilms Tumor 1 |
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| Retinitis Pigmentosa |
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| Speech Disorder |
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| Liver Leiomyosarcoma |
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| Meningioma, Familial |
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| Testicular Cancer |
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| Amyotrophic Lateral Sclerosis 1 |
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| Alzheimer Disease, Familial, 1 |
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| Parkinson Disease, Late-Onset |
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| Congenital Nervous System Abnormality |
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| Nervous System Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | CALB2 | VGNC | VGNC:26701 |
| Rattus norvegicus | CALB2 | RGD | RGD:620981 |
| Mus musculus | CALB2 | MGD | MGI:101914 |
| Macaca mulatta | CALB2 | VGNC | VGNC:104723 |
| Canis familiaris | CALB2 | VGNC | VGNC:38661 |
| Felis catus | CALB2 | VGNC | VGNC:60318 |
| Others | CALB2 | NCBI |