LST1 - leukocyte specific transcript 1 Gene

Also Known as B144; LST-1; D6S49E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7940

About LST1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,586,277-31,588,909 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele and 44 orthologues. Biased expression in bone marrow (RPKM 68.1), spleen (RPKM 43.9) and 13 other tissues.

Summary

The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

LST1 Products (6)

mRNA Protein Name
NM_001166538.1 NP_001160010.1 leukocyte-specific transcript 1 protein isoform 6
NM_007161.3 NP_009092.3 leukocyte-specific transcript 1 protein isoform 1
NM_205837.3 NP_995309.2 leukocyte-specific transcript 1 protein isoform 2
NM_205838.3 NP_995310.2 leukocyte-specific transcript 1 protein isoform 3
NM_205839.3 NP_995311.2 leukocyte-specific transcript 1 protein isoform 4
NM_205840.2 NP_995312.2 leukocyte-specific transcript 1 protein isoform 5

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in dendrite development IDA
IDA: Inferred from direct assay
11478849 GOA
involved in negative regulation of lymphocyte proliferation IDA
IDA: Inferred from direct assay
10706707 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11478849 GOA
located in membrane IDA
IDA: Inferred from direct assay
10706707 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LST1 Protein Structure

LST1

LST1: LST-1 protein (16 - 97)

  • 0
  • 97 a.a.
Protein Preferred Names Protein Names

leukocyte-specific transcript 1 protein

  • lymphocyte antigen 117

Related Diseases

Diseases Alias
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07867 LST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13352 SLCO1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22225 Lst1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28747 Lst1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LST1 RGD RGD:620077
Bos taurus LST1 VGNC VGNC:107291
Mus musculus LST1 MGD MGI:1096324
Others LST1 NCBI