ST7 - suppression of tumorigenicity 7 Gene

Also Known as HELG; RAY1; SEN4; TSG7; ETS7q; FAM4A; FAM4A1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7982

About ST7

Cytogenetic location: 7q31.2 Genomic coordinates (GRCh38): 7:116,953,501-117,230,176 (from NCBI)

This gene has 28 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 11.1), lung (RPKM 10.9) and 25 other tissues.

Summary

The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. [provided by RefSeq, Jul 2008]

ST7 Products (11)

mRNA	Protein	Name
NM_001369598.1	NP_001356527.1	suppressor of tumorigenicity 7 protein isoform 3
NM_001369599.1	NP_001356528.1	suppressor of tumorigenicity 7 protein isoform 1
NM_001369600.1	NP_001356529.1	suppressor of tumorigenicity 7 protein isoform 2
NM_001369601.1	NP_001356530.1	suppressor of tumorigenicity 7 protein isoform 4
NM_001369602.1	NP_001356531.1	suppressor of tumorigenicity 7 protein isoform 6
NM_001369603.1	NP_001356532.1	suppressor of tumorigenicity 7 protein isoform 7
NM_001369604.1	NP_001356533.1	suppressor of tumorigenicity 7 protein isoform 9
NM_001369606.1	NP_001356535.1	suppressor of tumorigenicity 7 protein isoform 10
NM_001369607.1	NP_001356536.1	suppressor of tumorigenicity 7 protein isoform 11
NM_018412.4	NP_060882.2	suppressor of tumorigenicity 7 protein isoform 5
NM_021908.3	NP_068708.1	suppressor of tumorigenicity 7 protein isoform 8

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30945288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST7 Protein Structure

ST7

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100
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585 a.a.

Protein Preferred Names	Protein Names
suppressor of tumorigenicity 7 protein	family with sequence similarity 4, subfamily A, member 1

Related Diseases

Diseases	Alias
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Gastric Dilatation	Stomach Dilatation
Facial Neuralgia
Neurilemmoma Of The Fifth Cranial Nerve	Trigeminal Schwannoma Trigeminal Neurilemmoma
Trigeminal Nerve Neoplasm	Neoplasm Of Trigeminal Nerve Tumor Of Trigeminal Nerve
Duodenal Obstruction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07795	LRP12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13854	ST7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13855	ST7L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18224	St7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24701	St7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ST7	VGNC	VGNC:49974
Felis catus	ST7	VGNC	VGNC:65734
Macaca mulatta	ST7	VGNC	VGNC:77899
Rattus norvegicus	ST7	RGD	RGD:1303148
Mus musculus	ST7	MGD	MGI:1927450
Canis familiaris	ST7	VGNC	VGNC:49656
Others	ST7	NCBI