TRMT2B - tRNA methyltransferase 2 homolog B Gene

Also Known as CXorf34; dJ341D10.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79979

About TRMT2B

This gene has 6 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 3.4), spleen (RPKM 3.4) and 25 other tissues.

Summary

This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]

TRMT2B Products (4)

mRNA	Protein	Name
NM_001167970.2	NP_001161442.1	tRNA (uracil-5-)-methyltransferase homolog B isoform a
NM_001167971.2	NP_001161443.1	tRNA (uracil-5-)-methyltransferase homolog B isoform b
NM_001167972.2	NP_001161444.1	tRNA (uracil-5-)-methyltransferase homolog B isoform a
NM_024917.6	NP_079193.2	tRNA (uracil-5-)-methyltransferase homolog B isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables rRNA (uridine-C5-)-methyltransferase activity	IDA IDA: Inferred from direct assay	31948311	GOA
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA IDA: Inferred from direct assay	31948311	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	27184847	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	31948311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT2B Protein Structure

Methyltransf_31

0
100
200
300
400
504 a.a.

Protein Preferred Names	Protein Names
tRNA (uracil-5-)-methyltransferase homolog B tRNA (uracil(54)-C(5))-methyltransferase homolog	TRM2 homolog

Protein Preferred Names

Protein Names

tRNA (uracil-5-)-methyltransferase homolog B

tRNA (uracil(54)-C(5))-methyltransferase homolog

TRM2 homolog

Related Diseases

Diseases	Alias
Loeys-Dietz Syndrome 4	LDS4 Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome Type 4 Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome, Type 4
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15092	TRMT2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRMT2B	VGNC	VGNC:79536
Rattus norvegicus	TRMT2B	RGD	RGD:1565132
Mus musculus	TRMT2B	MGD	MGI:2442530
Others	TRMT2B	NCBI