TRIM45 - tripartite motif containing 45 Gene

Also Known as RNF99

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80263

About TRIM45

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,111,060-117,123,927 (from NCBI)

This gene has 5 transcripts (splice variants), 185 orthologues and 80 paralogues. Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

TRIM45 Products (2)

mRNA Protein Name
NM_001145635.2 NP_001139107.1 tripartite motif-containing protein 45 isoform 2
NM_025188.4 NP_079464.2 tripartite motif-containing protein 45 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
28542145 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
36681779 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
36681779 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
36681779 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
36681779 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM45 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 55)

zf-B_box

zf-B_box: B-box zinc finger (133 - 175)

zf-B_box

zf-B_box: B-box zinc finger (188 - 224)

Filamin

Filamin: Filamin/ABP280 repeat (397 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 45

  • ring finger protein 99

Related Diseases

Diseases Alias
Erythematosquamous Dermatosis

  • Other Erythematosquamous Dermatosis
Birdshot Chorioretinopathy

  • Birdshot Chorioretinitis

  • Bscr

  • Birdshot Retinochoroiditis

  • Birdshot Retinochoroidopathy

  • Vitiliginous Choroiditis

  • Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15049 TRIM45 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19523 Ptgfrn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20610 Trim45 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27118 Trim45 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM45 VGNC VGNC:79169
Felis catus TRIM45 VGNC VGNC:66541
Bos taurus TRIM45 VGNC VGNC:36337
Mus musculus TRIM45 MGD MGI:1918187
Canis familiaris TRIM45 VGNC VGNC:47824
Rattus norvegicus TRIM45 RGD RGD:1309168
Others TRIM45 NCBI