2. Gene
  3. TRIM45 - tripartite motif containing 45 Gene

TRIM45 - tripartite motif containing 45 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RNF99

Gene ID: 80263 | Gene type: protein coding

About TRIM45

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:117,111,060-117,123,927 (from NCBI)

This gene has 5 transcripts (splice variants), 185 orthologues and 80 paralogues. Ubiquitous expression in endometrium (RPKM 2.4), thyroid (RPKM 2.2) and 24 other tissues.

Summary

This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

TRIM45 Products(2)

mRNA Protein Name
NM_001145635.2 NP_001139107.1 tripartite motif-containing protein 45 isoform 2
NM_025188.4 NP_079464.2 tripartite motif-containing protein 45 isoform 1

TRIM45 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 55)

zf-B_box

zf-B_box: B-box zinc finger (133 - 175)

zf-B_box

zf-B_box: B-box zinc finger (188 - 224)

Filamin

Filamin: Filamin/ABP280 repeat (397 - 494)

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  • 580 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 45

ring finger protein 99

Related Diseases

Diseases Alias
Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis
Birdshot Chorioretinopathy

Birdshot Chorioretinitis

Bscr

Birdshot Retinochoroiditis

Birdshot Retinochoroidopathy

Vitiliginous Choroiditis

Multiple Small, Cream-Colored Lesions, Symmetrically Scattered Mainly Around The Optic Disk
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15049 TRIM45 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TRIM45 VGNC VGNC:79169
Felis catus TRIM45 VGNC VGNC:66541
Bos taurus TRIM45 VGNC VGNC:36337
Mus musculus TRIM45 MGD MGI:1918187
Canis familiaris TRIM45 VGNC VGNC:47824
Rattus norvegicus TRIM45 RGD RGD:1309168