Trim2 - tripartite motif-containing 2 Gene

Also Known as narf; mKIAA0517

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80890

Summary

Enables ubiquitin protein Ligase activity. Involved in regulation of neuron apoptotic process. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Trim2 Products (5)

mRNA Protein Name
NM_001271725.1 NP_001258654.1 tripartite motif-containing protein 2 isoform 1
NM_001271726.1 NP_001258655.1 tripartite motif-containing protein 2 isoform 2
NM_001271727.1 NP_001258656.1 tripartite motif-containing protein 2 isoform 2
NM_001271728.1 NP_001258657.1 tripartite motif-containing protein 2 isoform 2
NM_030706.3 NP_109631.2 tripartite motif-containing protein 2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11432975 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
18687884 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18687884 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18687884 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tripartite motif-containing protein 2

  • E3 ubiquitin-protein ligase TRIM2

  • RING-type E3 ubiquitin transferase TRIM2

  • neural activity-related ring finger protein

  • tripartite motif protein 2

  • tripartite motif protein TRIM2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15025 TRIM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18191 Trim2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24665 Trim2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim2 NCBI NCBI:23321