Cxcr6 - chemokine (C-X-C motif) receptor 6 Gene

Also Known as BONZO; STRL33

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80901

About Cxcr6

Chromosome 9: 123,635,540-123,640,825 forward strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 97 orthologues, 25 paralogues and is associated with 2 phenotypes. Biased expression in mammary gland adult (RPKM 2.4), spleen adult (RPKM 2.2) and 14 other tissues.

Summary

Enables C-X-C chemokine binding activity and C-X-C Chemokine Receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human CXCR6 (C-X-C motif Chemokine Receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr6 Products (1)

mRNA Protein Name
NM_030712.4 NP_109637.3 C-X-C chemokine receptor type 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables C-X-C chemokine binding IPI
IPI: Inferred from physical interaction
11017100 MGI
enables C-X-C chemokine receptor activity IDA
IDA: Inferred from direct assay
11017100 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr6 Protein Structure

7tmA_CXCR6

7tmA_CXCR6: cd15173 (40 - 306)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (40 - 67)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (74 - 99)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (110 - 140)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (154 - 176)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (196 - 225)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (232 - 262)

7tmA_CXCR6

7tmA_CXCR6: cd15173 (275 - 300)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 6

  • CXC-R6

  • CXCR-6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122197 ML339 Antagonist 99.88% Unkown
HY-133151 CXCR6 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcr6 NCBI NCBI:10663