CXCR6 - C-X-C motif chemokine receptor 6 Gene

Homo sapiens

Also known as BONZO; CD186; CDw186; STRL33; TYMSTR

Gene ID: 10663 | Gene type: protein coding

About CXCR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,940,915-45,948,351 (from NCBI)

This gene has 4 transcripts (splice variants), 97 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC Chemokine Receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the Chemokine Receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]

CXCR6 Products(4)

mRNA	Protein	Name
NM_001386435.1	NP_001373364.1	C-X-C chemokine receptor type 6
NM_001386437.1	NP_001373366.1	C-X-C chemokine receptor type 6
NM_001386436.1	NP_001373365.1	C-X-C chemokine receptor type 6
NM_006564.2	NP_006555.1	C-X-C chemokine receptor type 6

CXCR6 Protein Structure

7tm_1

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

C-X-C chemokine receptor type 6

G protein-coupled receptor	G-protein coupled receptor STRL33
G-protein coupled receptor bonzo	chemokine (C-X-C motif) receptor 6

Related Diseases

Diseases

Alias

Type 1 Diabetes Mellitus 22

Diabetes Mellitus, Insulin-Dependent, 22	IDDM22
T1D22	Insulin-Dependent Diabetes Mellitus 22
Diabetes Mellitus, Insulin-Dependent, Type 22

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Cataract 44

CTRCT44	Total Early-Onset Cataract
Cataract 44 And Hypotrichosis	Cataract And Hypotrichosis
Cataract, Type 44

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122197	ML339	Antagonist	99.88%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CXCR6	MGD	MGI:1934582
Rattus norvegicus	CXCR6	RGD	RGD:1642118
Bos taurus	CXCR6	VGNC	VGNC:27858
Macaca mulatta	CXCR6	VGNC	VGNC:71423
Canis familiaris	CXCR6	VGNC	VGNC:39753
Felis catus	CXCR6	VGNC	VGNC:61300