CXCR6 - C-X-C motif chemokine receptor 6 Gene

Also Known as BONZO; CD186; CDw186; STRL33; TYMSTR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10663

About CXCR6

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,940,915-45,948,351 (from NCBI)

This gene has 4 transcripts (splice variants), 97 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues.

Summary

The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC Chemokine Receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the Chemokine Receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]

CXCR6 Products (4)

mRNA Protein Name
NM_001386435.1 NP_001373364.1 C-X-C chemokine receptor type 6
NM_001386437.1 NP_001373366.1 C-X-C chemokine receptor type 6
NM_001386436.1 NP_001373365.1 C-X-C chemokine receptor type 6
NM_006564.2 NP_006555.1 C-X-C chemokine receptor type 6

CXCR6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 288)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

C-X-C chemokine receptor type 6

  • G protein-coupled receptor

  • G-protein coupled receptor STRL33

  • G-protein coupled receptor bonzo

  • chemokine (C-X-C motif) receptor 6

CXCR6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83796 CD186 Antibody (YA3493) WB, FC, ELISA Human
HY-P83796A CD186 Antibody (YA3493)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 22

  • Diabetes Mellitus, Insulin-Dependent, 22

  • IDDM22

  • T1D22

  • Insulin-Dependent Diabetes Mellitus 22

  • Diabetes Mellitus, Insulin-Dependent, Type 22
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency Disease

  • Primary Immunodeficiency

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Cataract 44

  • CTRCT44

  • Total Early-Onset Cataract

  • Cataract 44 And Hypotrichosis

  • Cataract And Hypotrichosis

  • Cataract, Type 44
Sarcoidosis 1

  • Sarcoidosis

  • Boeck Sarcoid

  • Besnier-Boeck-Schaumann Disease

  • SS1

  • Sarcoidosis, Susceptibility To, 1

  • Lymphogranulomatosis

  • Hodgkin Disease

  • Boeck'S Disease

  • Boeck'S Sarcoid

  • Schaumann'S Disease Or Syndrome

  • Hutchinson-Boeck Disease Or Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122197 ML339 Antagonist 99.88% Unkown
HY-133151 CXCR6 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CXCR6 MGD MGI:1934582
Rattus norvegicus CXCR6 RGD RGD:1642118
Bos taurus CXCR6 VGNC VGNC:27858
Macaca mulatta CXCR6 VGNC VGNC:71423
Canis familiaris CXCR6 VGNC VGNC:39753
Felis catus CXCR6 VGNC VGNC:61300
Others CXCR6 NCBI