Polh - polymerase (DNA directed), eta (RAD 30 related) Gene

Also Known as XPV; RAD30A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80905

Summary

Enables DNA-directed DNA Polymerase activity. Acts upstream of or within cellular response to UV-C; postreplication repair; and pyrimidine dimer repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus; replication fork; and site of double-strand break. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Used to study xeroderma pigmentosum variant type. Human ortholog(s) of this gene implicated in xeroderma pigmentosum variant type. Orthologous to human POLH (DNA Polymerase eta). [provided by Alliance of Genome Resources, Apr 2022]

Polh Products (2)

mRNA Protein Name
NM_001364947.1 NP_001351876.1 DNA polymerase eta isoform 2
NM_030715.4 NP_109640.1 DNA polymerase eta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
10871396 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to UV-C IGI
IGI: Inferred from genetic interaction
17114294 MGI
acts upstream of or within cellular response to UV-C IMP
IMP: Inferred from mutant phenotype
17114294 MGI
acts upstream of or within postreplication repair IDA
IDA: Inferred from direct assay
10871396 MGI
acts upstream of or within pyrimidine dimer repair IDA
IDA: Inferred from direct assay
10871396 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase eta

  • DNA-directed DNA polymerase eta

  • RAD30 homolog A

  • xeroderma pigmentosum variant type protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22285 Polh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10831 POLH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28808 Polh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Polh NCBI NCBI:5429