Bmpr1a - bone morphogenetic protein receptor type 1A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81507

About Bmpr1a

Primary_assembly 16: 9,736,630-9,780,616 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 225 orthologues, 11 paralogues and is associated with 20 phenotypes. Biased expression in Heart (RPKM 257.6), Kidney (RPKM 251.6) and 9 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; enzyme activator activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of cell population proliferation; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; limb morphogenesis; and regionalization. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr1a Products (1)

mRNA Protein Name
NM_030849.2 NP_110476.1 bone morphogenetic protein receptor type-1A precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
21185359 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
21185359 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bmpr1a Protein Structure

Activin_recp

Activin_recp: pfam01064 (58 - 131)

TGF_beta_GS

TGF_beta_GS: pfam08515 (204 - 231)

STKc_BMPR1a

STKc_BMPR1a: cd14220 (237 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 532 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein receptor type-1A

  • ALK-3

  • BMP type-1A receptor

  • BMPR-1A

  • activin receptor-like kinase 3

  • bone morphogenetic protein 4 receptor

  • bone morphogenetic protein receptor, type IA

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P4087 Cys(Npys)-(Arg)9 / Unkown
HY-RS01546 BMPR1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01547 Bmpr1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01548 Bmpr1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174775 Human BMPR1A mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmpr1a NCBI NCBI:657