Actb - actin, beta Gene

Also Known as Actx

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81822

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to electrical stimulus; regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of norepinephrine uptake. Located in several cellular components, including actin cytoskeleton; membrane raft; and postsynaptic density. Part of protein-containing complex. Used to study non-alcoholic fatty liver disease. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Apr 2022]

Actb Products (1)

mRNA	Protein	Name
NM_031144.3	NP_112406.1	actin, cytoplasmic 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16530190	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12700184	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in axonogenesis	IDA IDA: Inferred from direct assay	12504890	RGD
involved in cellular response to electrical stimulus	IDA IDA: Inferred from direct assay	24657527	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	9483199	RGD
involved in regulation of cyclin-dependent protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	10683146	RGD
involved in regulation of norepinephrine uptake	IGI IGI: Inferred from genetic interaction	18331289	RGD
involved in regulation of norepinephrine uptake	IMP IMP: Inferred from mutant phenotype	18331289	RGD
involved in regulation of transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	18331289	RGD
involved in regulation of transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18331289	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	23289174	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	24780915	RGD
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	22916200	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	12504890	RGD
located in cytoskeleton	IDA IDA: Inferred from direct assay	10683146	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
located in podosome	IDA IDA: Inferred from direct assay	17111031	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15823548	RGD
located in stress fiber	IDA IDA: Inferred from direct assay	17111031	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
actin, cytoplasmic 1	beta-actin cytoplasmic beta-actin

Actb Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Actb	P60711	Wasf1	Rattus norvegicus	Q5BJU7	Anti Bait CoIP	16530190

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16025	EOC317	Inhibitor	98.01%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-184235	β-actin-IN-1	Inhibitor	/	Unkown
HY-N19906	Psoralenol	Inhibitor	/	Unkown
HY-RS00215	ACTB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10891	POTEF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185838	FAM-labeled Human beta-actin siRNA		/	Unkown
HY-RS17630	Actb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24090	Actb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actb	NCBI	NCBI:60