Glis2 - GLIS family zinc finger 2 Gene

Also Known as Nkl; Gli5; Klf16

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83396

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in cytoplasm; non-motile cilium; and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Glis2 Products (1)

mRNA	Protein	Name
NM_031184.3	NP_112461.2	zinc finger protein GLIS2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11262234	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21127075	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18298960	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17344476	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21127075	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell differentiation involved in kidney development	IMP IMP: Inferred from mutant phenotype	17618285	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	26880577	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	18227149	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	21127075	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11741991	MGI
involved in negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21816948	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17618285	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21127075	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17618285	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11741991	MGI
acts upstream of or within positive regulation of protein localization to nucleus	IGI IGI: Inferred from genetic interaction	17344476	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21127075	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18227149	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in non-motile cilium	IDA IDA: Inferred from direct assay	17618285	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	11741991	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18227149	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger protein GLIS2	GLI-Kruppel family member GLI5 GLI-similar 2 Kruppel-like factor 16 (neuronal) neuronal Krueppel-like protein zinc finger protein GLI5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13901	GANT 61		99.80%	Unkown
HY-RS05475	GLI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12487	NL-103	Inhibitor	/	Unkown
HY-137567	Prostaglandin E1 ethanolamide	Activator	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-RS05481	GLIS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20743	Gli2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21582	Glis2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27255	Gli2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28100	Glis2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glis2	NCBI	NCBI:84662