Pik3ap1 - phosphoinositide-3-kinase adaptor protein 1 Gene

Also Known as BCAP; 1810044J04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83490

Summary

Enables identical protein binding activity and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in regulation of inflammatory response; regulation of signal transduction; and Toll-like Receptor signaling pathway. Located in cytosol and plasma membrane. Orthologous to human PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Pik3ap1 Products (1)

mRNA	Protein	Name
NM_031376.4	NP_113553.1	phosphoinositide 3-kinase adapter protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15102471	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	20728433	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11163197	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20728433	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22187458	MGI
involved in positive regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20728433	MGI
NOT involved in regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	22187458	MGI
NOT involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22187458	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	22187460	MGI
involved in toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	22187460	MGI
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	22187458	MGI
involved in toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	22187458	MGI
involved in toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	22187458	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11163197	MGI
located in cytosol	IDA IDA: Inferred from direct assay	22187458	MGI
located in membrane	IDA IDA: Inferred from direct assay	22187458	MGI
NOT located in nucleus	IDA IDA: Inferred from direct assay	11163197	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11163197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphoinositide 3-kinase adapter protein 1	B cell phosphoinositide 3-kinase adaptor B-cell adapter for phosphoinositide 3-kinase B-cell phosphoinositide 3-kinase adapter protein 1

Pik3ap1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pik3ap1	Q9EQ32	Myd88	Mus musculus	P22366	Anti Bait CoIP	22187460
Intra	Pik3ap1	Q9EQ32	Pik3ap1	Mus musculus	Q9EQ32	Y2H	15102471
Intra	Pik3ap1	Q9EQ32	Tp53bp2	Mus musculus	Q8CG79	Y2H	15102471
Intra	Pik3ap1	Q9EQ32	Tirap	Mus musculus	Q99JY1	Anti Bait CoIP	22187460
Intra	Pik3ap1	Q9EQ32	Nck1	Mus musculus	Q99M51	Y2H	15102471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10510	PIK3AP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22016	Pik3ap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28534	Pik3ap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3ap1	NCBI	NCBI:118788