PIK3AP1 - phosphoinositide-3-kinase adaptor protein 1 Gene

Also Known as BCAP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118788

About PIK3AP1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:96,593,315-96,720,514 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in spleen (RPKM 34.0), lymph node (RPKM 33.6) and 19 other tissues.

Summary

Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and signaling receptor binding activity. Predicted to be involved in regulation of inflammatory response; regulation of signal transduction; and Toll-like Receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PIK3AP1 Products (1)

mRNA Protein Name
NM_152309.3 NP_689522.2 phosphoinositide 3-kinase adapter protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21706016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3AP1 Protein Structure

DBB

DBB: Dof, BCAP, and BANK (DBB) motif, (179 - 318)

  • 0
  • 200
  • 400
  • 600
  • 805 a.a.
Protein Preferred Names Protein Names

phosphoinositide 3-kinase adapter protein 1

  • B cell adaptor protein

PIK3AP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PIK3AP1 Q6ZUJ8 GRB2 Homo sapiens P62993
Y2H
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pharyngitis

  • Acute Pharyngitis

  • Chronic Pharyngitis

  • Acute Sore Throat

  • Chronic Sore Throat

  • Persistent Sore Throat

  • Pharyngeal Diseases

  • Chronic Pharyn/Nasopharyngitis

  • Chronic Pharyngitis And Nasopharyngitis

  • Inflamed Throat

  • Pharyngeal Disease

  • Pharyngeal Disorder

  • Pharyngitis - Acute

  • Sore Throat - Chronic

  • Acute Pharyngitis Nos

  • Acute Sore Throat Nos

  • Acute Throat Inflammation

  • Infective Pharyngitis

  • Infection Of Pharynx

  • Acute Infective Pharyngitis

  • Acute Infective Pharyngitis Nos

  • Acute Pharyngeal Inflammation

  • Inflammation Of The Throat

  • Throat Inflammation

  • Throat Infection

  • Putrid Pharyngitis

  • Pharyngeal Inflammation

  • Pharyngitis Nos

  • Chronic Throat Pain

  • Throat Catarrh
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10510 PIK3AP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22016 Pik3ap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28534 Pik3ap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PIK3AP1 VGNC VGNC:64176
Bos taurus PIK3AP1 VGNC VGNC:54469
Macaca mulatta PIK3AP1 VGNC VGNC:75891
Mus musculus PIK3AP1 MGD MGI:1933177
Canis familiaris PIK3AP1 VGNC VGNC:44550
Rattus norvegicus PIK3AP1 RGD RGD:1307744
Others PIK3AP1 NCBI