Tirap - toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Gene

Also Known as Mal; Wyatt; Tlr4ap; C130027E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 117149

Summary

Enables Toll-like Receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cytokine production. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; myeloid cell differentiation; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Tirap Products (4)

mRNA Protein Name
NM_001177845.1 NP_001171316.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_001177846.1 NP_001171317.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_001177847.1 NP_001171318.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_054096.2 NP_473437.2 toll/interleukin-1 receptor domain-containing adapter protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Toll-like receptor 2 binding IPI
IPI: Inferred from physical interaction
17322885 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
11544529 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
16751103 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11544529 MGI
enables signaling adaptor activity IMP
IMP: Inferred from mutant phenotype
11526399 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway IPI
IPI: Inferred from physical interaction
11526399 MGI
acts upstream of or within cellular response to bacterial lipopeptide IMP
IMP: Inferred from mutant phenotype
15690042 MGI
acts upstream of or within cellular response to lipoteichoic acid IMP
IMP: Inferred from mutant phenotype
15690042 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
15690042 MGI
NOT involved in interleukin-1-mediated signaling pathway IDA
IDA: Inferred from direct assay
11544529 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
15690042 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
11526399 MGI
involved in positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
12447442 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12447442 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
11526399 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
IMP: Inferred from mutant phenotype
16301656 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: Inferred from mutant phenotype
16301656 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
16301656 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
12447442 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
12421970 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
12447442 MGI
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
16301656 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
15690042 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: Inferred from mutant phenotype
18039275 MGI
involved in positive regulation of toll-like receptor 3 signaling pathway IDA
IDA: Inferred from direct assay
17322885 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15690042 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
12447442 MGI
involved in regulation of interferon-beta production IDA
IDA: Inferred from direct assay
14630816 MGI
involved in regulation of interleukin-15 production IMP
IMP: Inferred from mutant phenotype
18583567 MGI
involved in toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
11526399 MGI
NOT involved in toll-like receptor 5 signaling pathway IMP
IMP: Inferred from mutant phenotype
12447442 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
15690042 MGI
Cellular Component GO Annotation Evidence References Source
located in endocytic vesicle IDA
IDA: Inferred from direct assay
16751103 MGI
NOT located in peroxisome IDA
IDA: Inferred from direct assay
20451243 MGI
located in ruffle membrane IDA
IDA: Inferred from direct assay
16751103 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

toll/interleukin-1 receptor domain-containing adapter protein

  • TIR domain-containing adapter protein

  • Toll-like receptor 4 adaptor protein

  • adaptor protein Wyatt

  • myD88 adapter-like protein

Tirap Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tirap Q99JY1 Pik3ap1 Mus musculus Q9EQ32
Anti Tag CoIP
22187460
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14551 TIRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19486 Tirap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25980 Tirap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tirap NCBI NCBI:114609