Vamp8 - vesicle-associated membrane protein 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83730

Summary

Enables SNAP receptor activity and syntaxin binding activity. Involved in protein-containing complex assembly and vesicle fusion. Located in endosome; lysosomal membrane; and midbody. Part of SNARE complex. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Vamp8 Products (1)

mRNA Protein Name
NM_031827.2 NP_114015.1 vesicle-associated membrane protein 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNAP receptor activity IDA
IDA: Inferred from direct assay
15133481 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
14668490 RGD
enables syntaxin binding IPI
IPI: Inferred from physical interaction
15133481 RGD
Biological Process GO Annotation Evidence References Source
involved in membrane fusion IDA
IDA: Inferred from direct assay
19109692 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
10336434 RGD
involved in vesicle fusion IDA
IDA: Inferred from direct assay
15133481 RGD
involved in vesicle-mediated transport IDA
IDA: Inferred from direct assay
15133481 RGD
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
11786915 RGD
located in late endosome membrane IDA
IDA: Inferred from direct assay
15133481 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
15133481 RGD
located in midbody IDA
IDA: Inferred from direct assay
12737809 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
10468577 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicle-associated membrane protein 8

  • EDB

  • VAMP-8

  • endobrevin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10809 VAMP Inhibitor 98.13% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15599 VAMP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19045 Vamp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25535 Vamp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vamp8 NCBI NCBI:8673