HDHD2 - haloacid dehalogenase like hydrolase domain containing 2 Gene

Also Known as HEL-S-301; 3110052N05Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84064

About HDHD2

This gene has 13 transcripts (splice variants), 201 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 11.6), thyroid (RPKM 10.9) and 25 other tissues.

Summary

Enables enzyme binding activity. Predicted to be involved in dephosphorylation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

HDHD2 Products (2)

mRNA Protein Name
NM_001318765.2 NP_001305694.1 haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 2
NM_032124.5 NP_115500.1 haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
22939629 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDHD2 Protein Structure

Hydrolase_6

Hydrolase_6: Haloacid dehalogenase-like hydrolase (10 - 88)

Hydrolase_like

Hydrolase_like: HAD-hyrolase-like (177 - 246)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

haloacid dehalogenase-like hydrolase domain-containing protein 2

  • epididymis secretory protein Li 301

HDHD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDHD2 Q9H0R4 LHPP Homo sapiens Q9H008
Anti Tag CoIP
33961781
Intra
HDHD2 Q9H0R4 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HDHD2 Proteins

Cat. No. Product Name Accession Purity
HY-P70912 HDHD2 Protein, Human (His) Q9H0R4-1 (M1-L259) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chromosome 18q Deletion Syndrome

  • 18q- Syndrome

  • Monosomy 18q

  • Deletion Of Long Arm Of Chromosome 18

  • Chromosome 18q- Syndrome

  • Deletion 18q

  • 18q Deletion Syndrome

  • Distal 18q Deletion Syndrome

  • Chromosome 18 Long Arm Deletion Syndrome

  • Chromosome 18q Monosomy

  • Del Syndrome

  • Chromosome 18 Deletion Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06097 HDHD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21592 Hdhd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28110 Hdhd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HDHD2 MGD MGI:1924237
Bos taurus HDHD2 VGNC VGNC:108122
Rattus norvegicus HDHD2 RGD RGD:1308579
Canis familiaris HDHD2 VGNC VGNC:41628
Felis catus HDHD2 VGNC VGNC:62773
Macaca mulatta HDHD2 VGNC VGNC:103825
Others HDHD2 NCBI