NOA1 - nitric oxide associated 1 Gene

Also Known as MTG3; hNOA1; C4orf14; hAtNOS1; mAtNOS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84273

About NOA1

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:56,963,350-56,977,606 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 6 paralogues. Ubiquitous expression in colon (RPKM 10.1), duodenum (RPKM 8.9) and 25 other tissues.

Summary

The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]

NOA1 Products (1)

mRNA Protein Name
NM_032313.4 NP_115689.1 nitric oxide-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
19103604 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19103604 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
19103604 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with matrix side of mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19103604 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOA1 Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (340 - 501)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
Protein Preferred Names Protein Names

nitric oxide-associated protein 1

  • mitochondrial GTPase 3 homolog

NOA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NOA1 Q8NC60 NDUFA9 Homo sapiens Q16795
Pull Down
19103604
Intra
NOA1 Q8NC60 NDUFA9 Homo sapiens Q16795
Anti Bait CoIP
19103604
Intra
NOA1 Q8NC60 DAP3 Homo sapiens P51398
Anti Bait CoIP
19103604
Intra
NOA1 Q8NC60 DAP3 Homo sapiens P51398
Pull Down
19103604
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcomatosis
Spinocerebellar Ataxia 28

  • Spinocerebellar Ataxia Type 28

  • SCA28

  • Ataxia, Spinocerebellar, Type 28
Cerebrooculofacioskeletal Syndrome 1

  • Cofs Syndrome

  • COFS1

  • Pena-Shokeir Syndrome Type 2

  • Cofs

  • Pena-Shokeir Syndrome, Type Ii

  • Cerebrooculofacioskeletal Syndrome

  • Cerebro-Oculo-Facio-Skeletal Syndrome 1

  • Pena Shokeir Syndrome Type 2
Cardiomyopathy, Dilated, 1e

  • Left Ventricular Noncompaction 9

  • Left Ventricular Noncompaction 5

  • Dilated Cardiomyopathy 1e

  • Dilated Cardiomyopathy 1s

  • CMD1E

  • Cdcd2

  • Cardiomyopathy, Dilated, 1y

  • CMD1Y

  • Cardiomyopathy, Dilated, 1s

  • CMD1S

  • Dilated Cardiomyopathy 1y

  • Dilated Cardiomyopathy With Conduction Defect 2

  • Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia

  • Cardiomyopathy, Dilated, With Conduction Defect 2

  • Cardiomyopathy Dilated With Conduction Defect Type 2

  • Cardiomyopathy, Dilated 1e

  • Cardiomyopathy, Dilated 1s

  • Cardiomyopathy, Dilated 1y

  • Left Ventricular Non-Compaction 5

  • LVNC5

  • Left Ventricular Non-Compaction 9

  • LVNC9

  • Cardiomyopathy, Dilated, Type 1e

  • Cardiomyopathy, Dilated, Type 1s

  • Cardiomyopathy, Dilated, Type 1y
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09397 NOA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22262 Noa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28784 Noa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NOA1 VGNC VGNC:63843
Bos taurus NOA1 VGNC VGNC:56755
Macaca mulatta NOA1 VGNC VGNC:75269
Mus musculus NOA1 MGD MGI:1914306
Rattus norvegicus NOA1 RGD RGD:1359460
Canis familiaris NOA1 VGNC VGNC:43871
Others NOA1 NCBI