LBX2 - ladybird homeobox 2 Gene

Also Known as LP3727

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85474

About LBX2

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,497,517-74,503,316 (from NCBI)

This gene has 6 transcripts (splice variants), 322 orthologues and 1 paralogue. Biased expression in liver (RPKM 2.5), small intestine (RPKM 1.7) and 11 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including muscle cell differentiation; positive regulation of convergent extension involved in gastrulation; and positive regulation of non-canonical Wnt signaling pathway. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

LBX2 Products (2)

mRNA Protein Name
NM_001009812.2 NP_001009812.1 transcription factor LBX2 isoform 2
NM_001282430.2 NP_001269359.1 transcription factor LBX2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LBX2 Protein Structure

Homeobox

Homeobox: Homeobox domain (86 - 142)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

transcription factor LBX2

  • ladybird homeobox protein homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07547 LBX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LBX2 VGNC VGNC:42604
Mus musculus LBX2 MGD MGI:1342288
Felis catus LBX2 VGNC VGNC:63202
Rattus norvegicus LBX2 RGD RGD:1561172
Bos taurus LBX2 VGNC VGNC:30806
Macaca mulatta LBX2 VGNC VGNC:84894
Others LBX2 NCBI