CBLN1 - cerebellin 1 precursor Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 869

About CBLN1

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:49,277,917-49,281,838 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 3 paralogues. Biased expression in fat (RPKM 8.8), testis (RPKM 8.3) and 9 other tissues.

Summary

This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. [provided by RefSeq, Aug 2008]

CBLN1 Products (1)

mRNA Protein Name
NM_004352.4 NP_004343.1 cerebellin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27418511 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
27418511 GOA
involved in positive regulation of long-term synaptic depression IMP
IMP: Inferred from mutant phenotype
27418511 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBLN1 Protein Structure

C1q

C1q: C1q domain (63 - 190)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

cerebellin-1

  • precerebellin

Related Diseases

Diseases Alias
Postsurgical Hypothyroidism

  • Postoperative Hypothyroidism

  • Post-Surgical Hypothyroidism
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02001 CBLN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CBLN1 VGNC VGNC:26811
Rattus norvegicus CBLN1 RGD RGD:1562813
Macaca mulatta CBLN1 VGNC VGNC:70556
Mus musculus CBLN1 MGD MGI:88281
Canis familiaris CBLN1 VGNC VGNC:38761
Others CBLN1 NCBI