SLC7A6 - solute carrier family 7 member 6 Gene

Also Known as LAT3; LAT-2; y+LAT-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9057

About SLC7A6

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,264,526-68,301,819 (from NCBI)

This gene has 17 transcripts (splice variants), 232 orthologues and 12 paralogues. Ubiquitous expression in fat (RPKM 11.5), lymph node (RPKM 10.0) and 24 other tissues.

Summary

Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transmembrane transport and ornithine transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A6 Products (2)

mRNA Protein Name
NM_001076785.3 NP_001070253.1 Y+L amino acid transporter 2
NM_003983.6 NP_003974.3 Y+L amino acid transporter 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-arginine transmembrane transporter activity IDA
IDA: Inferred from direct assay
11311135 GOA
enables L-lysine:L-arginine antiporter activity IDA
IDA: Inferred from direct assay
10903140 GOA
enables arginine binding IDA
IDA: Inferred from direct assay
19562367 GOA
enables basic amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17197568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
10903140 GOA
involved in L-arginine transmembrane transport IMP
IMP: Inferred from mutant phenotype
31705628 GOA
involved in L-leucine transport IDA
IDA: Inferred from direct assay
16785209 GOA
involved in neutral amino acid transport IDA
IDA: Inferred from direct assay
10903140 GOA
involved in ornithine transport IMP
IMP: Inferred from mutant phenotype
17197568 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A6 Protein Structure

AA_permease_2

AA_permease_2: Amino acid permease (45 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 515 a.a.
Protein Preferred Names Protein Names

Y+L amino acid transporter 2

  • amino acid permease

SLC7A6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC7A6 Q92536 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lysinuric Protein Intolerance

  • LPI

  • Dibasic Amino Aciduria Ii

  • Hyperdibasic Aminoaciduria

  • Dibasic Aminoaciduria 2

  • Dibasicamino Aciduria Ii

  • Congenital Lysinuria

  • Lpi - Lysinuric Protein Intolerance
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Cystinuria

  • CSNU

  • Cystinuria Type B

  • Cystinuria Type A

  • Cystinuria, Type I, Formerly

  • Csnu1, Formerly

  • Cystinuria, Type Ii, Formerly

  • Cystinuria, Type Iii, Formerly

  • Csnu3, Formerly

  • Cystinuria, Type Non-I, Formerly

  • Cystinuria-Lysinuria

  • Cystinuria-Lysinuria Syndrome

  • Csnu1

  • Csnu3

  • Cystinuria 1

  • Cystinuria Type A/B

  • Cystinuria Type I

  • Cystinuria Type Ii

  • Cystinuria Type Iii

  • Cystinuria Type Non-I

  • Cystinuria, Type A/B

  • Cystinuria Type 1

  • Cystinuria - Lysinuria

  • Csnu - [Cystinuria]

  • Cystine Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13332 SLC7A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13333 SLC7A6OS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC7A6 VGNC VGNC:34931
Canis familiaris SLC7A6 VGNC VGNC:46476
Mus musculus SLC7A6 MGD MGI:2142598
Rattus norvegicus SLC7A6 RGD RGD:1309193
Macaca mulatta SLC7A6 VGNC VGNC:104751
Felis catus SLC7A6 VGNC VGNC:65427
Others SLC7A6 NCBI